L4897

Luteinizing hormone releasing hormone salmon

≥97% (HPLC)

• Synonym(s): GnRH, Gonadoliberin, Gonadotropin releasing hormone, LH-RH
• Empirical Formula (Hill Notation): C₆₀H₇₃N₁₅O₁₃
• CAS Number: 86073-88-3
• Molecular Weight: 1212.31
• NACRES: NA.32
• PubChem Substance ID: 24896381
• UNSPSC Code: 51111800
• MDL number: MFCD00133497

Properties

• Quality Segment: 200
• assay: ≥97% (HPLC)
• UniProt accession no.: P55248, P01148, P07490, P13562, P30968, P30969, Q01776
• storage temp.: −20°C
• SMILES string: CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(Cc3ccc(O)cc3)NC(=O)C(CO)NC(=O)C(Cc4c[nH]c5ccccc45)NC(=O)C(Cc6cnc[nH]6)NC(=O)C7CCC(=O)N7)C(=O)N8CCCC8C(=O)NCC(N)=O
• InChI: 1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)
• InChI key: NMJREATYWWNIKX-UHFFFAOYSA-N
• Gene Information: human ... GNRH1(2796), GNRHR(2798) ; mouse ... GNRH1(14714), GNRHR(14715) ; rat ... GNRH1(25194), GNRHR(81668)

Description

Application

Luteinizing hormone releasing hormone (salmon) has been used to study the effect of LHRH (luteinizing hormone releasing hormone) in the brain of Podarcis sicula sicula (male) during reproduction.[1] It has been used to study the hormonal regulation of PACAP (pituitary adenylate cyclase-activating polypeptide) and its receptor, PAC1 (adenylate cyclase activating polypeptide 1 (pituitary) receptor type I).[2]

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.

Stimulates release of gonadotrophins from anterior pituitary.

Other Notes

Lyophilized from 0.5% acetic acid

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H360
• pcodes: P201 - P308 + P313
• Hazard Classifications: Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges