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Iodoacetamide

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About This Item

Linear Formula:

ICH₂CONH₂

CAS Number:

144-48-9

Molecular Weight:

184.96

EC Number:

205-630-1

UNSPSC Code:

12352202

NACRES:

NA.21

Beilstein/REAXYS Number:

1739080

MDL number:

MFCD00008028

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Properties

biological source

synthetic

Quality Segment

400

assay

≥99% (NMR)

form

powder

mp

92-95 °C (lit.)

solubility

H₂O: 0.5 M, clear, colorless

suitability

suitable for manufacturing use

storage temp.

2-8°C

SMILES string

NC(=O)CI

InChI

1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)

InChI key

PGLTVOMIXTUURA-UHFFFAOYSA-N

Description

General description

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Biochem/physiol Actions

Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibiting ribonuclease.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item	I1149	I6125	407710
SAFC I5161 Iodoacetamide	Sigma-Aldrich I1149 Iodoacetamide	Sigma-Aldrich I6125 Iodoacetamide	Sigma-Aldrich 407710 α-Iodoacetamide
description -	description BioUltra	description ≥99% (NMR), crystalline	description α-Iodoacetamide, CAS 144-48-9, is an irreversible inhibitor of several cysteine proteases.
biological source synthetic	biological source synthetic (organic)	biological source synthetic (organic)	biological source -
form powder	form powder	form crystalline	form crystalline solid
assay ≥99% (NMR)	assay ≥99% (NMR)	assay ≥99% (NMR)	assay ≥99% (HPLC)
suitability suitable for manufacturing use	suitability -	suitability -	suitability -
solubility H₂O: 0.5 M, clear, colorless	solubility H₂O: 0.5 M, clear, colorless	solubility H₂O: soluble 0.5 M, clear, colorless	solubility methanol: 1:20, DMF: soluble, ethanol: soluble, water: soluble
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C

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Pictograms

GHS06,GHS08

Signal Word

Danger

Hazard Codes

H301,H317,H334,H413

Precautionary Statements

P261 - P264 - P273 - P280 - P301 + P310 - P302 + P352

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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