H2292
Histone H3.1 human
Synonym(s):
Histone, Human
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About This Item
Form:
liquid
Biological source:
human
Recombinant:
expressed in E. coli
Pricing and availability is not currently available.
biological source
human
Quality Level
recombinant
expressed in E. coli
form
liquid
concentration
1 mg/mL
technique(s)
MALDI-TOF: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... H3C1(8350)
General description
Application
Histone H3.1 human has been used in in vitro Schizosaccharomyces pombe Set7 histone methyltransferase assay for matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) studies.[4]
Biochem/physiol Actions
Histone H3.1 human (H3.1) undergoes a majority of post-translational modification especially acetylation and demethylation in lysine 14 and 9 respectively.[1] During differentiation, the levels of H3.1 transcripts decrease as cell division slows down.[2] The incorporation of H3.1 into chromatin is mediated by a chaperone, chromatin assembly factor (CAF-1).[1] A transversion mutation in the H3.1 may be implicated in glioma.[3]
Physical form
Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.
1 of 1
This Item | |||
|---|---|---|---|
| biological source human | biological source human | biological source human | biological source human |
| technique(s) MALDI-TOF: suitable | technique(s) - | technique(s) - | technique(s) - |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| concentration 1 mg/mL | concentration 1 mg/mL | concentration 1 mg/mL | concentration 1 mg/mL |
| form liquid | form liquid | form liquid | form liquid |
| Gene Information human ... H3C1(8350) | Gene Information human ... H1.0(3005) | Gene Information human ... H2AC20(8338) | Gene Information human ... H2BC1(255626) |
signalword
Warning
hcodes
flash_point_f
Not applicable
flash_point_c
Not applicable
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
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Gang Wu et al.
Nature genetics, 44(3), 251-253 (2012-01-31)
To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found
Sandra B Hake et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(17), 6428-6435 (2006-03-31)
In the history of science, provocative but, at times, controversial ideas have been put forward to explain basic problems that confront and intrigue the scientific community. These hypotheses, although often not correct in every detail, lead to increased discussion that
Yunpeng Shen et al.
Structure (London, England : 1993), 27(4), 631-638 (2019-02-19)
Histone methylation by histone methyltransferases (HMTases) has a key role in transcriptional regulation. Discrepancies between the known HMTases and the histone lysine methylome suggest that HMTases remain to be identified. Here we report the discovery, characterization, and crystal structure of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H2292-100UG | 04061833234631 |