EPS003

CUDC 101

A potent inhibitor of HDACs and receptor tyrosine kinases

• Synonym(s): 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide, Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy
• Empirical Formula (Hill Notation): C₂₄H₂₆N₄O₄
• CAS Number: 1012054-59-9
• Molecular Weight: 434.49
• MDL number: MFCD15528940
• UNSPSC Code: 12352200
• NACRES: NA.41
• Assay: ≥98% (HPLC)

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• color: white
• solubility: DMSO: soluble
• storage temp.: −20°C
• SMILES string: N(O)C(=O)CCCCCCOc1cc2c(ncnc2Nc3cc(ccc3)C#C)cc1OC
• InChI: 1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
• InChI key: PLIVFNIUGLLCEK-UHFFFAOYSA-N

Description

General description

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively.

Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable