E0656

ER-27319

≥98% (HPLC), solid

• Synonym(s): 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate
• Empirical Formula (Hill Notation): C₂₀H₂₂N₂O₅
• CAS Number: 201010-95-9
• Molecular Weight: 370.40
• NACRES: NA.77
• PubChem Substance ID: 24724472
• UNSPSC Code: 12352200
• MDL number: MFCD07784502

Properties

• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: 28 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(=O)C(O)=O.Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C
• InChI: 1S/C18H20N2O.C2H2O4/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21;3-1(4)2(5)6/h3-4,6-9H,5,10-11,19H2,1-2H3;(H,3,4)(H,5,6)
• InChI key: IIELZHYJYZBSGG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ER-27319 inhibits Syk activation with an IC₅₀ = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.[1]

Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364 - P501
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable