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Dithranol

Name: Dithranol
Brand: SIGMA

≥90% (HPLC)

Synonym(s):

1,8,9-Anthracenetriol, 1,8-Dihydroxy-9(10H)-anthracenone, 1,8-Dihydroxyanthrone, Anthralin

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₀O₃

CAS Number:

1143-38-0

Molecular Weight:

226.23

UNSPSC Code:

12352201

NACRES:

NA.25

PubChem Substance ID:

24893712

EC Number:

214-538-0

Beilstein/REAXYS Number:

2054360

MDL number:

MFCD00053409

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Properties

Quality Level

200

assay

≥90% (HPLC)

form

solid

mp

178-181 °C (lit.)

solubility

chloroform: 20 mg/mL, clear to very slightly hazy, yellow

SMILES string

Oc1cccc2Cc3cccc(O)c3C(=O)c12

InChI

1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2

InChI key

NUZWLKWWNNJHPT-UHFFFAOYSA-N

Gene Information

mouse ... Alox12(11684)

Description

General description

Dithranol (1, 8 - dihydroxy-9-anthrone) is also called as anthralin. It is a vital topical antipsoriatic drugs.[1] Dithranol, an athracene derivative, is a free radical generating mitochondrial poison that induces apoptosis in keratinocytes.

Application

Dithranol, a potential anti-psoriasis medication, may be used to study its safety, efficacy, metabolism and pharmacological profile. Dithranol may be used to study is physicochemical properties, as a reference compound and to develop effective drug delivery vehicles.[2] Dithranol may be used as a matrix for matrix assisted laser desorption/ionization imaging on a Fourier transform ion cyclotron resonance mass spectrometer.[3]

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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This Item	D2953000	PHR1677	BP385
Sigma-Aldrich D2773 Dithranol	D2953000 Dithranol	Supelco PHR1677 Anthralin (Dithranol)	BP385 Dithranol
assay ≥90% (HPLC)	assay -	assay -	assay -
Quality Level 200	Quality Level -	Quality Level 300	Quality Level -
solubility chloroform: 20 mg/mL, clear to very slightly hazy, yellow	solubility -	solubility -	solubility -
form solid	form -	form -	form powder
mp 178-181 °C (lit.)	mp 178-181 °C (lit.)	mp 178-181 °C (lit.)	mp 178-181 °C (lit.)
Gene Information mouse ... Alox12(11684)	Gene Information -	Gene Information -	Gene Information -

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Enhanced dye-sensitized solar cell photocurrent and efficiency using a Y-shaped, pyrazine-containing heteroaromatic sensitizer linkage.

Brian L Watson et al.

Physical chemistry chemical physics : PCCP, 17(24), 15788-15796 (2015-05-29)

A new sensitizer motif for dye sensitized solar cells (DSSC) has been developed. A heteroaromatic moiety containing a pyrazine ring links two porphyrin chromophores to the metal oxide surface via two carboxylic acid attachment groups. A test DSSC sensitized with

Effects of anthralin on mitochondrial bioenergetics.

C Salet et al.

Archives of dermatological research, 283(3), 186-190 (1991-01-01)

Isolated mitochondria were used to determine what causes anthralin inhibition of oxidative phosphorylation. In good agreement with other results, the rate of oxygen consumption was not modified by anthralin when mitochondria were first uncoupled with FCCP, suggesting that only the

Effects of the antipsoriatic drug dithranol on E2A and caspase-9 gene expression in vitro.

C Ronpirin et al.

Genetics and molecular research : GMR, 11(1), 412-420 (2012-03-01)

Although the precise causes of psoriasis remain to be elucidated, psoriasis has been known as a disorder in which factors in the immune system, enzymes and other biochemical substances that regulate skin cell division are functionally imbalanced, thereby resulting in

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Global Trade Item Number

SKU	GTIN
D2773-1G	04061833562512
D2773-5G	04061833562529

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Dithranol

≥90% (HPLC)

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About This Item

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mp

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