MMMP3MAG-79K
MILLIPLEX® Mouse MMP Magnetic Bead Panel 3 - Immunology Multiplex Assay
MMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple MMP biomarkers in mouse cell culture samples.
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84
Recommended Products
Quality Level
species reactivity
mouse
manufacturer/tradename
Milliplex®
assay range
standard curve range: 12-50,000 pg/mL
(MMP-8)
standard curve range: 12-50,000 pg/mL
(proMMP-9)
standard curve range: 2-10,000 pg/mL
(MMP-3)
standard curve range: 49-200,000 pg/mL
(MMP-2)
standard curve range: 5-20,000 pg/mL
(MMP-12)
technique(s)
multiplexing: suitable
detection method
fluorometric (Luminex xMAP)
shipped in
wet ice
General description
The MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in autoimmune disease, arthritis, cardiovascular disease, and tumor growth and metastasis.
MILLIPLEX® Mouse MMP Bead Panel 3, MMMP3MAG-79K, is a 5 plex kit to be used for the simultaneous quantification of any or all of the following analytes in tissue culture samples: MMP-2, MMP-3, MMP-8, proMMP-9, and MMP-12.
Panel Type: Cytokines/Chemokines
MILLIPLEX® Mouse MMP Bead Panel 3, MMMP3MAG-79K, is a 5 plex kit to be used for the simultaneous quantification of any or all of the following analytes in tissue culture samples: MMP-2, MMP-3, MMP-8, proMMP-9, and MMP-12.
Panel Type: Cytokines/Chemokines
Specificity
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Application
- Analytes: MMP-2, MMP-3, MMP-8, proMMP-9, MMP-12
- Recommended Sample type: cell/tissue culture supernatant or extracts
- Research Category: Inflammation & Immunology
Features and Benefits
Design your multiplex kit by choosing available analytes within this panel.
Storage and Stability
Recommended storage for kit components is 2 - 8°C.
Other Notes
Sensitivity: See protocol for sensitivities of individual analytes
Legal Information
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
Target Organs
Respiratory Tract
Storage Class Code
10 - Combustible liquids
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