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1.09843

Sigma-Aldrich

Neo-Clear™ Xylene Substitute

(xylene substitute) for microscopy

Synonym(s):

Neo-Clear™

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About This Item

CAS Number:
64741-65-7
MDL number:
MFCD00287158
UNSPSC Code:
41116113
EC Index Number:
265-067-2
NACRES:
NA.21
Pricing and availability is not currently available.

vapor pressure

6 hPa ( 20 °C)

Quality Level

400

form

liquid

autoignition temp.

240 °C

potency

>5000 mg/kg LD50, oral (Rat)
>5000 mg/kg LD50, skin (Rabbit)

expl. lim.

0.6 % (v/v)

IVD

for in vitro diagnostic use

color

clear

refractive index

n20/D 1.418

kinematic viscosity

1.3 cSt(20 °C)

mp

-20 °C

transition temp

flash point 43 °C

density

0.78-0.795 g/cm3 at 20 °C

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

15-25°C

General description

Neo-Clear™ (xylene substitute) - for microscopy, is an aliphatic hydrocarbon mixture that can substitute the same applications as xylene in the histo-medical lab - histoprocessing, deparaffination and clearing after dehydration in staining process. It is not necessary to change methods or incubation times when using Neo-Clear™ instead of xylene. As the evaporation rate of Neo-Clear™ is lower then xylene, it has less odor and the disturbing smell in the lab is reduced significantly. Neo-Clear™ is more sensitive against water in solvents (turbidity can occur), thus, it is essential to avoid technical qualities of solvents. It is an IVD registered product and CE certified, thus can be used for clinical diagnostic purposes. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.

Legal Information

NEO-CLEAR is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameHealth hazard
GHS02,GHS08

Signal Word

Danger

Hazard Statements

H226 - H304 - H413

Hazard Classifications

Aquatic Chronic 4 - Asp. Tox. 1 - Flam. Liq. 3

Supplementary Hazards

EUH066

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

110.3 °F

Flash Point(C)

43.5 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Questions

1–2 of 2 Questions  

  1. Is the solvent Neo Clear 1.09843.5000 compatible with a xylene-based mounting medium, or there is any recommendation of any other mounting medium?

    1 answer

    1. Neo Clear is best used with Neo Mount, while Xylene should be avoided.

      Helpful?

  2. Is it possible to use NeoClear with paraffin tissue that was initially processed using Xylene?

    1 answer

    1. After embedding the slides in paraffin, Neoclear or Xylene can be used to clear the slides and remove the paraffin before staining. If NeoClear is chosen, NeoMount should serve as the permanent mounting media. It is generally not recommended to use NeoClear and a xylene-based permanent mounting media, as the standard practice in histology is to use a clearing agent that matches the permanent mounting media. If an aqueous mounting media is utilized, the slides are stained, washed in water, and then coverslipped with the aqueous mounting media. In the case of aqueous mounting media, the slides do not undergo NeoClear or Xylene treatment.

      Helpful?

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