764736
Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)-block-decane
PEG average Mn 2,000, PDLLA average Mn 2,000
Synonym(s):
PEG-PDLLA-decane, PEG-b-PLA-b-decane, PEG-PLA
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About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
Recommended Products
form
pellets
mol wt
PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)
degradation timeframe
2-5 weeks
transition temp
Tm 29-33 °C
PDI
<1.1 (typical PEG)
<1.2
<1.3 (overall)
storage temp.
2-8°C
General description
Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†
Application
Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
>230.0 °F
Flash Point(C)
> 110 °C
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