This material is practically insoluble in water at 0.4 mg/mL Additional solvents include the following:
DMSO at 50 mg/mL
methanol at 12 mg/mL
chloroform at 18 mg/mL
propyleneglycol at 25 mg/mL
benzyl alcohol at 72 mg/mL
dimethylacetamide at 138 mg/mL
T7883
Trimetoprim
≥98.5%
Sinónimos:
2,4-Diamino-5-(3,4,5-trimetoxibencil)pirimidina, NSC 106568
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About This Item
Fórmula empírica (notación de Hill):
C14H18N4O3
Número de CAS:
Peso molecular:
290.32
Beilstein/REAXYS Number:
625127
EC Number:
MDL number:
UNSPSC Code:
51285203
PubChem Substance ID:
NACRES:
NA.85
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Quality Level
assay
≥98.5%
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
color
white to light yellow
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mode of action
DNA synthesis | interferes
enzyme | inhibits
storage temp.
2-8°C
SMILES string
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI
1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChI key
IEDVJHCEMCRBQM-UHFFFAOYSA-N
Gene Information
human ... DHFRP1(573971) , KCNH1(3756)
rat ... Dhfr(24312)
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General description
Estructura química: pirimidina
Application
El trimetoprim se utiliza principalmente como agente antibacteriano. Tiene actividad inhibidora de la dihidrofolato reductasa con selectividad por la enzima procariota. Se utiliza para tratar infecciones de las vías urinarias, prostatitis aguda leve, cistitis recurrente, bacteriuria asintomática durante el embarazo e infecciones del sistema respiratorio[1].
Se utiliza principalmente como un antibacteriano. Inhibidor de la dihidrofolato reductasa con selectividad por la enzima procariota.
Biochem/physiol Actions
La combinación de trimetoprim y sulfametoxazol interfiere en el metabolismo celular del ácido fólico en la célula bacteriana al bloquear la biosíntesis de los nucleótidos. El trimetoprim se une a la dihidrofolato reductasa e inhibe la reducción del ácido dihidrofólico (DHF) a ácido tetrahidrofólico (THF). El THF es un precursor esencial en la vía de síntesis de timidina y la interferencia con esta vía inhibe la síntesis bacteriana de ADN[1].
Packaging
5G, 25G, 100G
Other Notes
Mantenga el recipiente herméticamente cerrado y en un lugar bien ventilado. Consérvese en un lugar seco.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Is it soluable in water or dmso and at what concentration should I use it?
1 answer-
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Is Trimethoprim stable in solution?
1 answer-
Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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