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Merck

T7515

Sigma-Aldrich

Sodium taurolithocholate

Sinónimos:

3α-Hydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide, Taurolithocholic acid sodium salt

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About This Item

Fórmula lineal:
C26H44NO5SNa
Número de CAS:
Peso molecular:
505.69
UNSPSC Code:
12161900
PubChem Substance ID:
NACRES:
NA.25

description

anionic

Quality Level

assay

≥97.0% (TLC)

mol wt

505.69 g/mol

application(s)

detection

SMILES string

C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na]

InChI

1S/C26H45NO5S.Na.H/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3;;/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32);;/t17-,18-,19-,20+,21-,22+,23+,25+,26-;;/m1../s1

InChI key

CMXYYIRKQPXCIE-RLHFEMFKSA-N

General description

Sodium taurolithocholate is a bile salt with detergent qualities that give it the ability to solubilize insoluble lipids.

Application

Sodium taurolithocholate has been used in a study to assess factors controlling the gastrointestinal adsorption of petroleum hydrocarbon residues. It has also been used in a study to investigate the decrease in activity of Na+, K+-adenosinetriphosphatase (Na+, K+-ATPase) in rats where cholestasis had been induced.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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David M Booth et al.
Gastroenterology, 140(7), 2116-2125 (2011-03-01)
Oxidative stress is implicated in the pathogenesis of pancreatitis, but clinical trials of antioxidants have produced conflicting results. We examined the role of intracellular reactive oxygen species (ROS) in pancreatic acinar cell injury. Freshly isolated murine and human pancreatic acinar
Gerald U Denk et al.
Hepatology (Baltimore, Md.), 52(5), 1758-1768 (2010-11-03)
NorUDCA (24-norursodeoxycholic acid), the C₂₃-homolog of ursodeoxycholic acid (UDCA), showed remarkable therapeutic effects in cholestatic Mdr2 (Abcb4) (multidrug resistance protein 2/ATP-binding cassette b4) knockout mice with sclerosing/fibrosing cholangitis. In contrast to UDCA, norUDCA is inefficiently conjugated in human and rodent
Kjell B Døving et al.
The Journal of experimental biology, 214(Pt 1), 80-87 (2010-12-15)
In the present study, we exposed the olfactory epithelia of crucian carp, Carassius carassius, and brown trout, Salmo trutta, to dextran coupled with Alexa dyes together with odorants. Dye uptake was severely reduced after pre-exposure to nocodazole, an inhibitor of
Barbara Döring et al.
Current topics in membranes, 70, 105-168 (2012-11-28)
The SLC10 family represents seven genes containing 1-12 exons that encode proteins in humans with sequence lengths of 348-477 amino acids. Although termed solute carriers (SLCs), only three out of seven (i.e. SLC10A1, SLC10A2, and SLC10A6) show sodium-dependent uptake of
Which way to die: the regulation of acinar cell death in pancreatitis by mitochondria, calcium, and reactive oxygen species.
Anna S Gukovskaya et al.
Gastroenterology, 140(7), 1876-1880 (2011-04-29)

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Contenido relacionado

Bile Acids (BA) are synthesized in the liver and play important roles in cholesterol homeostasis, absorption of vitamins and lipids, and various key metabolic processes.

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