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T6901

Sigma-Aldrich

α1-Mating Factor acetate salt

≥93% (HPLC), synthetic

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About This Item

Fórmula empírica (notación de Hill):
C82H114N20O17S
Número de CAS:
59401-28-4
Peso molecular:
1683.97
MDL number:
MFCD00133883
UNSPSC Code:
51111800
PubChem Substance ID:
24900413
NACRES:
NA.32

biological source

synthetic

Quality Level

200

assay

≥93% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C1CCCN1C(=O)C(CCC(N)=O)NC(=O)CNC(=O)C2CCCN2C(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc3c[nH]c4ccccc34)NC(=O)C(Cc5cnc[nH]5)NC(=O)C(N)Cc6c[nH]c7ccccc67)C(=O)NC(Cc8ccc(O)cc8)C(O)=O

InChI

1S/C82H114N20O17S/c1-45(2)34-61(98-76(112)63(38-49-41-89-56-17-9-7-15-53(49)56)99-77(113)64(39-50-42-87-44-91-50)96-71(107)54(84)37-48-40-88-55-16-8-6-14-52(48)55)74(110)93-57(25-27-68(85)104)72(108)97-62(35-46(3)4)75(111)95-59(18-10-11-30-83)80(116)101-31-12-19-66(101)78(114)90-43-70(106)92-60(26-28-69(86)105)81(117)102-32-13-20-67(102)79(115)94-58(29-33-120-5)73(109)100-65(82(118)119)36-47-21-23-51(103)24-22-47/h6-9,14-17,21-24,40-42,44-46,54,57-67,88-89,103H,10-13,18-20,25-39,43,83-84H2,1-5H3,(H2,85,104)(H2,86,105)(H,87,91)(H,90,114)(H,92,106)(H,93,110)(H,94,115)(H,95,111)(H,96,107)(H,97,108)(H,98,112)(H,99,113)(H,100,109)(H,118,119)

InChI key

SBKVPJHMSUXZTA-UHFFFAOYSA-N

Amino Acid Sequence

Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr

Application

α1-Mating Factor acetate salt has been used for the synchronization of yeast cells for flow cytometry and to study B-type cyclin (Clb2p)-EmCitrine levels from calcofluor white treated cells.

Biochem/physiol Actions

The α1-Mating factor is a pheromone produced by yeast that regulates mating. α1-Mating Factor acetate salt can be utilized to arrest the G1-phase of the cell cycle in various yeast strains.

Preparation Note

Alpha1-Mating Factor acetate salt dissolves in water at 1 mg/ml to yield a clear, colorless solution.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
SLCR5753
0000285684
SLCG3459
SLCD2450
SLBV6517

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Journal of molecular recognition : JMR, 28(1), 1-9 (2015-06-06)
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Brianna L Greenwood et al.
Methods in molecular biology (Clifton, N.J.), 2579, 145-168 (2022-09-01)
The cell division cycle is a fundamental process required for proliferation of all living organisms. The eukaryotic cell cycle follows a basic template with an ordered series of events beginning with G1 (Gap1) phase, followed successively by S (Synthesis) phase
Mingliang Zhang et al.
Eukaryotic cell, 1(5), 811-822 (2002-11-29)
Fungal adhesins represent a large family of serine/threonine-rich secreted glycoproteins. Adhesins have been shown to play roles in heterotypic and homotypic cell-cell adhesion processes, morphogenetic pathways and invasive/pseudohyphal growth, frequently in response to differentiation cues. Here we address the role
Stefano Vernarecci et al.
Molecular and cellular biology, 28(3), 988-996 (2007-11-28)
We report that the histone acetyltransferase Gcn5p is involved in cell cycle progression, whereas its absence induces several mitotic defects, including inefficient nuclear division, chromosome loss, delayed G(2) progression, and spindle elongation. The fidelity of chromosome segregation is finely regulated
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The Journal of cell biology, 220(12) (2021-11-18)
In eukaryotes, chromatin binding to the inner nuclear membrane (INM) and nuclear pore complexes (NPCs) contributes to spatial organization of the genome and epigenetic programs important for gene expression. In mitosis, chromatin-nuclear envelope (NE) interactions are lost and then formed
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