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T0675

Sigma-Aldrich

[D-Ala2]-Deltorphin II

≥97% (HPLC)

Sinónimos:

Tyr-D-Ala-Phe-Glu-Val-Val-Gly amide

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About This Item

Fórmula empírica (notación de Hill):
C38H54N8O10
Número de CAS:
122752-16-3
Peso molecular:
782.88
MDL number:
MFCD00080072
UNSPSC Code:
12352209
PubChem Substance ID:
24899907
NACRES:
NA.32

biological source

synthetic (organic)

Quality Level

200

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)C)C(=O)NCC(N)=O

InChI

1S/C38H54N8O10/c1-20(2)31(37(55)41-19-29(40)48)46-38(56)32(21(3)4)45-35(53)27(15-16-30(49)50)43-36(54)28(18-23-9-7-6-8-10-23)44-33(51)22(5)42-34(52)26(39)17-24-11-13-25(47)14-12-24/h6-14,20-22,26-28,31-32,47H,15-19,39H2,1-5H3,(H2,40,48)(H,41,55)(H,42,52)(H,43,54)(H,44,51)(H,45,53)(H,46,56)(H,49,50)/t22-,26+,27+,28+,31+,32+/m1/s1

InChI key

NUNBRHVOPFWRRG-RCEFDBTISA-N

Gene Information

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)
mouse ... Oprd1(18386) , Oprm1(18390)
rat ... Oprd1(24613) , Oprm1(25601)

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Amino Acid Sequence

Tyr-Ala-Phe-Glu-Val-Val-Gly-NH2

Biochem/physiol Actions

Selective δ2 opioid receptor agonist

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Agnès Poirier et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2434-2444 (2008-09-24)
The use of in vitro data for quantitative predictions of transporter-mediated elimination in vivo requires an accurate estimation of the transporter Michaelis-Menten parameters, V(max) and K(m), as a first step. Therefore, the experimental conditions of in vitro studies used to
V Otis et al.
Neuroscience, 183, 221-229 (2011-04-05)
Over the past few years, significant progress has been made in cancer therapy. Indeed, the lifespan of cancer patients has significantly increased. Although patients live longer, cancer-related pain remains a daily problem affecting their quality of life, especially when metastases
H Beaudry et al.
Neuroscience, 161(2), 381-391 (2009-03-31)
In the present study, we asked whether multiple intrathecal injections of deltorphin II, a selective delta opioid receptor (DOPR) agonist, induced DOPR tolerance in three behavioral assays. Unilateral inflammation caused by complete Freund's adjuvant (CFA) injection into the rat or
Klára Gyires et al.
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 10(3), 121-125 (2008-10-30)
Beta-endorphin, deltorphin II, [D-Ala2, Phe4, Gly5-ol-enkephalin (DAGO) as well as endomorphin-1 and endomorphin-2 injected intracerebroventricularly (i.c.v.) induced gastroprotective action. It has been raised that endogenous opioids may have a central role in maintaining gastric mucosal integrity. Therefore we aimed to
Xiaoli Zeng et al.
The Journal of surgical research, 169(2), 267-276 (2010-05-07)
Studies have documented the beneficial roles of δ opioid receptor (OR) agonist for hemorrhagic shock. However, the myocardial protection roles and the mechanisms of hemodynamic stability during resuscitation of δ-OR agonist have not been explored. This study was designed to
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