SRP8059

Jagged-2 (human): FC (human)

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

• Sinónimos: Alpha-ketoglutarate-dependent dioxygenase FTO, Protein jagged-2, hJ2
• Código UNSPSC: 12352200
• NACRES: NA.32

Propiedades

• recombinante: expressed in HEK 293 cells
• Ensayo: ≥90% (SDS-PAGE)
• Formulario: lyophilized
• mol peso: ~150 kDa by SDS-PAGE
• impurezas: <0.1 EU/μgtested
• Nº de acceso UniProt: Q9Y219
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... JAG2(3714)

Descripción

Descripción general

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

Secuencia

Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.

Forma física

Lyophilized. Contains PBS + 0.02 % CHAPS.

Reconstitución

Reconstitute with 100μl sterile water.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable