Vedaprofen is a non-steroidal anti-inflammatory drug (NSAID) that has been found to have antimicrobial activity. Vedaprofen is primarily used as a veterinary analgesic and anti-inflammatory for arthritis and pain. Its anti-inflammatory activity is due to cyclooxygenase inihbition, while its antimicrobial activity is less certain. Vedaprofen can kill B. subtilis by permeabilizing its membrane. Other studies have shown vedaprofen can target the Escherichia coli DNA polymerase III β subunit.
This prospective randomized blinded clinical study aimed to investigate the potential of vedaprofen for preventive analgesia, comparing its analgesic effects with ketoprofen administered post-operatively in dogs undergoing maxillectomy or mandibulectomy. Pain control was effective and rescue analgesia was not necessary
Evidence suggests that some nonsteroidal anti-inflammatory drugs (NSAIDs) possess antibacterial properties with an unknown mechanism. We describe the in vitro antibacterial properties of the NSAIDs carprofen, bromfenac, and vedaprofen, and show that these NSAIDs inhibit the Escherichia coli DNA polymerase III
ACS chemical biology, 11(8), 2222-2231 (2016-05-20)
Increasing antimicrobial resistance has become a major public health crisis. New antimicrobials with novel mechanisms of action (MOA) are desperately needed. We previously developed a method, bacterial cytological profiling (BCP), which utilizes fluorescence microscopy to rapidly identify the MOA of
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