SMB00912

Pseudouridine

≥98% (HPLC)

• Sinónimos: Pseudouridine, β-Pseudouridine, ψ-Uridine, 5-(β-D-Ribofuranosyl)uracil
• Fórmula empírica (notación de Hill): C₉H₁₂N₂O₆
• Número de CAS: 1445-07-4
• Peso molecular: 244.20
• UNSPSC Code: 41106305
• NACRES: NA.79

Propiedades

• biological source: synthetic (chemical)
• Quality Level: 200
• assay: ≥98% (HPLC)
• form: powder
• mol wt: 244.2
• color: white to off-white
• mp: 222 °C ((432 °F ))
• solubility: water: soluble
• storage temp.: 2-8°C
• SMILES string: [nH]1[c]([nH]cc([c]1=O)[C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=O
• InChI: 1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1
• InChI key: PTJWIQPHWPFNBW-GBNDHIKLSA-N

Descripción

General description

Pseudouridine (Ψ) stands as an isomer of the nucleoside uridine, featuring a carbon-carbon bond instead of the typical nitrogen-carbon glycosidic bond connecting uracil. It represents the most prevalent among the myriad modified nucleosides within RNA, with a presence spanning various species and RNA classes. The enzymatic action of Ψ synthases induces post-transcriptional isomerization of specific uridine residues, a process known as pseudouridylation. This modification, particularly in rRNA and tRNA, plays a vital role in fine-tuning and stabilizing regional structures, contributing to mRNA decoding, ribosome assembly, processing, and translation functions. Moreover, β-pseudouridine, identified in tRNAs across bacteria, archaea, and eukaryotes, has demonstrated potential in reducing radiation-induced chromosome aberrations in human lymphocytes. Its utility as a cancer and proliferation biomarker positions it as a valuable asset in metabolomics and biochemical research.

Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a β-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite. Pseudouridine is found in all species and in all classes of RNA except mRNA. It is formed by enzymes called pseudouridine synthases, which post-transcriptionally isomerize specific uridine residues in RNA.

Application

Pseudouridine is a versatile compound and a biomarker that finds application in metabolomics and biochemical research.

Features and Benefits

• High-purity compound suitable for a wide variety of research applications

Other Notes

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Información de seguridad

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable