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S0520

Sigma-Aldrich

Selenocystamine dihydrochloride

>98% (TLC), suitable for ligand binding assays

Sinónimos:

2,2′-diselenobis-Ethanamine hydrochloride (1:2)

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About This Item

Fórmula empírica (notación de Hill):
C4H12N2Se2 · 2HCl
Número de CAS:
3542-13-0
Peso molecular:
318.99
MDL number:
MFCD00035445
UNSPSC Code:
12352116
PubChem Substance ID:
24899440
NACRES:
NA.26

Nombre del producto

Selenocystamine dihydrochloride, powder

assay

>98% (TLC)

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

yellow to orange

solubility

H2O: soluble, clear to slightly hazy

SMILES string

NCC[Se][Se]CCN.[H]Cl.[H]Cl

InChI

1S/C4H12N2Se2.ClH/c5-1-3-7-8-4-2-6;/h1-6H2;1H

InChI key

PKRYDZYGNSZBHO-UHFFFAOYSA-N

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General description

Selenocystamine dihydrochloride has a potential to block the activity of influenza A and B virus associated RNA-dependent RNA polymerase enzyme.

Application

Selenocystamine dihydrochloride has been used to determine its effect on PP2A phosphatase activity in vitro. It has also been used as a catalyst for a disulfide-cleaving reagent, dithiothreitol (DTT).

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000410100
0000404707
0000404635
0000307311
0000410100

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L Chen et al.
Free radical biology & medicine, 19(6), 713-724 (1995-12-01)
A selenium (Se)-containing immunoconjugate of a human anti-erythrocyte membrane antibody (Ab-Se) has been synthesized via oxidation of the carbohydrate moieties of the antibody and covalent coupling with selenocystamine. The isolated Ab-Se immunoconjugate is shown to be more hemolytic than is
T Tabatabaie et al.
Toxicology and applied pharmacology, 141(2), 389-393 (1996-12-01)
Chronic benzaldehyde exposure is known to cause central nervous system (CNS) disturbances. Previous studies have shown that benzaldehyde causes the formation of reactive oxygen species (ROS) in rat synaptosomal fractions. Benzaldehyde has also been implicated in ROS formation in the
M S Stewart et al.
Free radical biology & medicine, 26(1-2), 42-48 (1999-01-16)
The cancer chemopreventive effect of selenium cannot be fully accounted for by the role of selenium as a component of the antioxidant enzyme glutathione peroxidase, which suggests that chemoprevention occurs by another mechanism. Several studies have shown that thiol oxidation
Wansik Cha et al.
Biomaterials, 28(1), 19-27 (2006-09-09)
Novel nitric oxide (NO) generating polymeric materials possessing immobilized organoselenium species are described. These materials mimic the capability of small organoselenium molecules as well as a known selenium-containing enzyme, glutathione peroxidase (GPx), by catalytically decomposing S-nitrosothiols (RSNO) into NO and
L Tatum et al.
Biological trace element research, 77(3), 241-249 (2001-02-24)
The purpose of this study was to investigate the ameliorating effects of dietary copper supplementation on selenium toxicity. Nine groups (n = 6) of weanling Fischer 344 female rats were randomly assigned to treatment groups and fed diets containing nontoxic
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