MSQC8

SigmaMAb Antibody Drug Conjugate (ADC) Mimic

Name: SigmaMAb Antibody Drug Conjugate (ADC) Mimic
Brand: SIGMA

Antibody Cysteine-Fluorophore Conjugate Standard

Sinónimos:

Antibody Drug Conjugate

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UNSPSC Code:

12352204

NACRES:

NA.32

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recombinant

expressed in CHO cells

Quality Level

200

antibody product type

primary antibodies

form

lyophilized powder

shipped in

wet ice

storage temp.

−20°C

Categorías relacionadas

Protein Mass Spectrometry

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Este artículo	MSQC28	MSQC26	MSQC4
Sigma-Aldrich MSQC8 SigmaMAb Antibody Drug Conjugate (ADC) Mimic	Sigma-Aldrich MSQC28 SILu^™Lite SigmaMAb Vedolizumab Monoclonal Antibody	Sigma-Aldrich MSQC26 SILu^™Lite SigmaMAb Nivolumab Monoclonal Antibody	Sigma-Aldrich MSQC4 SILu^™Lite SigmaMAb Universal Antibody Standard human
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice
form lyophilized powder	form solid	form solid	form -
recombinant expressed in CHO cells	recombinant expressed in CHO cells	recombinant expressed in CHO cells	recombinant expressed in CHO cells
antibody product type primary antibodies	antibody product type -	antibody product type -	antibody product type -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200

General description

SigmaMab Antibody Drug Conjugate (ADC) Mimic, is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic conjugates SigmaMab (MSQC4), an IgG1 monoclonal antibody, to dansyl fluorophores via an LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves as the substitution for the toxic payload of a real ADC.

The ADC Mimic allows for safer and more consistent testing, making it the optimal product over real ADCs. It is also a more affordable product compared to real ADCs. With the help of this non-toxic product, LC-MS processes can be developed in a safer environment.

Application

Poster: Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Poster: LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Poster: LC-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC Mimic

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Clase de almacenamiento

11 - Combustible Solids

wgk_germany

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

0000470442

0000448819

0000428925

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Rapid Analysis of Biotherapeutics Using Protein A Chromatography Coupled to Orbitrap Mass Spectrometry.

Craig Jakes et al.

Analytical chemistry, 93(40), 13505-13512 (2021-09-30)

Monoclonal antibodies (mAbs) and related products undergo a wide range of modifications, many of which can often be directly associated to culture conditions during upstream processing. Ideally, such conditions should be monitored and fine-tuned based on real-time or close to

Contenido relacionado

Data Sheet - MSQC8

Instructions

Questions

1–2 of 2 Questions

2 years ago

Is the primary sequence of the antibody available?

1 answer
1. Technical Support
  
  2 years ago
  
  SigmaMAb Antibody Drug Conjugate (ADC) Mimic consists of the human universal monoclonal antibody standard (Catalog Number MSQC4, an IgG1 monoclonal antibody) conjugated to dansyl fluorophores via an LC-SMCC crosslinker.
  The sequence of MSQC4 can be found in the user guide. Sequence Information:
  1. SigmaMAb Heavy Chain:
  EVQLVESGGGLVQPGGSLRLSCVASGFTLNNYD MHWVRQGIGKGLEWVSKIGTAGDRYYAGSVKGR FTISRENAKDSLYLQMNSLRVGDAAVYYCARGAG RWAPLGAFDIWGQGTMVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNS TYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPI EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLT CLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPG
  2. SigmaMAb Light Chain:
  QSALTQPRSVSGSPGQSVTISCTGTSSDIGGYNF VSWYQQHPGKAPKLMIYDATKRPSGVPDRFSGS KSGNTASLTISGLQAEDEADYYCCSYAGDYTPGV VFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANK ATLVCLISDFYPGAVTVAWKADSSPVKAGVETTT PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT HEGSTVEKTVAPTECS
  
  Helpful?
2 years ago

Does MSQC8 (SigmaMAb Antibody Drug Conjugate (ADC) Mimic) has light chain lambda or gamma?

1 answer
1. Technical Support
  
  2 years ago
  
  This antibody has both lambda light chains and gamma heavy chains.
  
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SigmaMAb Antibody Drug Conjugate (ADC) Mimic