G3127
Gly-Sar
≥98% (TLC)
Sinónimos:
Glycyl-sarcosine
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About This Item
Fórmula lineal:
NH2CH2CON(CH3)CH2COOH
Número de CAS:
Peso molecular:
146.14
Beilstein/REAXYS Number:
1768450
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
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Nombre del producto
Gly-Sar,
assay
≥98% (TLC)
Quality Level
form
powder
color
white
mp
198 °C
storage temp.
−20°C
SMILES string
CN(CC(O)=O)C(=O)CN
InChI
1S/C5H10N2O3/c1-7(3-5(9)10)4(8)2-6/h2-3,6H2,1H3,(H,9,10)
InChI key
VYAMLSCELQQRAE-UHFFFAOYSA-N
Gene Information
human ... SLC15A1(6564)
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Jinling Wang et al.
International journal of nanomedicine, 13, 7997-8012 (2018-12-13)
Polymeric micelles (PMs) hold promise for improving solubility and oral absorption of poorly soluble drugs. Unfortunately, the oral absorption of PMs is also limited by intestinal epithelium. To improve the oral delivery efficiency of micelles, transporter-mediated micelles could enhance the
Hovhannes J Gukasyan et al.
Pharmaceutical research, 34(12), 2488-2497 (2017-08-24)
Studies were conducted in primary cultured rat alveolar epithelial cell monolayers to characterize peptide transporter expression and function. Freshly isolated rat lung alveolar epithelial cells were purified and cultured on permeable support with and without keratinocyte growth factor (KGF). Messenger
Junji Miyabe et al.
Journal of pharmacological sciences, 139(3), 215-222 (2019-03-06)
Boron neutron capture therapy (BNCT) is a radiotherapy utilizing the neutron capture and nuclear fission reaction of 10B taken up into tumor cells. The most commonly used boron agent in BNCT, p-borono-l-phenylalanine (BPA), is accumulated in tumors by amino acid
Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1.
Ina Hubatsch et al.
Journal of medicinal chemistry, 50(21), 5238-5242 (2007-09-25)
The hPepT1-mediated transport properties of a series of 11 synthesized beta- and gamma-peptides have been studied in Caco-2 cells. The results show that several of the compounds interact with the peptide transporter, but only two beta-dipeptides act as substrates and
Kanae Kawai et al.
Molecular therapy. Methods & clinical development, 17, 49-57 (2020-01-01)
Because many peptide and peptide-mimetic drugs are substrates of peptide transporter 1, it is important to evaluate the peptide transporter 1-mediated intestinal absorption of drug candidates in the early phase of drug development. Although intestinal cell lines treated with inhibitors
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