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D8941

Sigma-Aldrich

2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide

≥98% (HPLC), solid

Sinónimos:

PEPA

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About This Item

Fórmula empírica (notación de Hill):
C16H16N2O4S2F2
Número de CAS:
141286-78-4
Peso molecular:
402.44
MDL number:
MFCD04974493
UNSPSC Code:
12352200
PubChem Substance ID:
24278571
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white

solubility

DMSO: >20 mg/mL

SMILES string

NC(=O)COc1c(F)cc(SCCNS(=O)(=O)c2ccccc2)cc1F

InChI

1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)

InChI key

GTACSIONMHMRPD-UHFFFAOYSA-N

Gene Information

human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Biochem/physiol Actions

2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
128K4718
102K4707

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Weisheng Chen et al.
Neuroscience letters, 612, 126-131 (2015-12-08)
Infralimbic cortex (IL) is proposed to suppress cocaine seeking after extinction, but whether the IL regulates the extinction and reinstatement of heroin-seeking behavior is unknown. To address this issue, the male SD rats were trained to self-administer heroin under a
Amirbek Bekeshev et al.
Polymers, 12(7) (2020-07-02)
The conducted studies have proven the possibility of the directed control of operational properties of epoxy composites, due to the addition of finely-ground ocher into their composition, and the use of microwave modification of the epoxy composition. The rational content
Yanchao Xu et al.
Journal of colloid and interface science, 565, 23-34 (2020-01-14)
Nanofiltration (NF) membranes with tannic acid (TA) based selective layers have been intensively studied in recent years, but they still suffer from poor inorganic salt rejection. This study provided a first report on mussel-inspired co-deposition of TA and amine to
Quan-Guang Zhang et al.
Hippocampus, 20(1), 65-77 (2009-03-31)
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are responsible for excitotoxicity induced by ischemic injury in hippocampal CA1 neurons, whereas the molecular mechanisms responsible for their neurotrophic activities are much less studied. Here, we examined the neuroprotective effect of positive modeulation of AMPARs
Clarissa Perez Faria et al.
Scientific reports, 10(1), 6234-6234 (2020-04-12)
The protozoan Giardia lamblia is the most common cause of parasitic gastrointestinal infection worldwide. The parasite developed sophisticated, yet not completely disclosed, mechanisms to escape immune system and growth in the intestine. To further understand the interaction of G. lamblia
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