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Merck

D8893

Sigma-Aldrich

Dexametasona

powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

Sinónimos:

(11β,16α)-9-Fluoro-11,17,21-trihidroxi-16-metilpregna-1,4-dieno-3,20-diona, 9α-Fluoro-16α-metil-11β,17α,21-trihidroxi-1,4-pregnadieno-3,20-diona, 9α-fluoro-16α-metilprednisolona, Prednisolona F

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About This Item

Fórmula empírica (notación de Hill):
C22H29FO5
Número de CAS:
Peso molecular:
392.46
Beilstein:
2066651
Número CE:
Número MDL:
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

synthetic (organic)

Nivel de calidad

esterilidad

γ-irradiated

Línea del producto

BioXtra

Ensayo

≥80% (HPLC)

Formulario

powder

potencia

4-500 ng/mL

técnicas

cell culture | mammalian: suitable

mp

262-264 °C (lit.)

solubilidad

ethanol: 1 mL/vial, clear

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

cadena SMILES

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

Clave InChI

UREBDLICKHMUKA-CXSFZGCWSA-N

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Aplicación

Dexamethasone has been used as a component of osteogenic differentiation medium.[1][2][3] It has also been used to study apoptosis, cell signaling pathways and gene expression.

Acciones bioquímicas o fisiológicas

Glucocorticoide antiinflamatorio
Glucocorticoide antiinflamatorio. Regula la supervivencia, el crecimiento y la diferenciación de las células T. Inhibe la inducción de la óxido nítrico sintasa.
Dexamethasone has immunosuppressant and antiemetic properties. It is used to treat postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV).[4] Dexamethasone plays an important role in cardiac transplant, sepsis, cancer and other pathologic disorders. It elevates the level of heat shock proteins.[5] It is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression.

Forma física

powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitución

To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

Pictogramas

Health hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificados de análisis (COA)

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

The Unfolded Protein Response and Cellular Stress, Part 2 (2011)
Substrate elasticity regulates adipose-derived stromal cell differentiation towards osteogenesis and adipogenesis through $\beta$-catenin transduction
Xie J, et al.
Acta Biomaterialia, 79(5), 83-95 (2018)
Bimolecular based heparin and self-assembling hydrogel for tissue engineering applications
Fernandez-Muinos T, et al.
Acta Biomaterialia, 16(5), 35-48 (2015)
Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application (2013)
C A Smith et al.
Journal of tissue engineering and regenerative medicine, 9(5), 595-604 (2014-06-20)
Fresh-frozen biological allograft remains the most effective substitute for the 'gold standard' autograft, sharing many of its osteogenic properties but, conversely, lacking viable osteogenic cells. Tissue engineering offers the opportunity to improve the osseointegration of this material through the addition

Questions

1–6 of 6 Questions  
  1. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  2. What is the solubility of Product D8893, Dexamethasone, in ethanol?

    1 answer
    1. The product is soluble in 95% ethanol (1mg/mL), yielding a clear, colorless solution. A 20 μg/mL stock solution can be formed by adding 49 mL of media to 1 mL of a 1 mg/mL ethanol stock.

      Helpful?

  3. What is the best way to dissolve Product D8893, Dexamethasone?

    1 answer
    1. The solubility of dexamethasone is <0.01 mg/mL in water and 24 mg/mL in H5784 (a 45% w/v solution of 2-hydroxypropyl-β-cyclodextrin).

      Helpful?

  4. How do the dexamethasone products D8893 and the D4902 compare?

    1 answer
    1. They are the same except for the sterility. D8893 has been g-irradiated, so it is sterile. The D4902 is not necessarily sterile. Both are cell culture tested by Sigma.

      Helpful?

  5. What is the solubility of Product D8893, Dexamethasone, in DMSO?

    1 answer
    1. The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.

      Helpful?

  6. What solution stability information do you have available for Product D8893, Dexamethasone?

    1 answer
    1. We would recommend that you store stock solutions in working aliquots frozen at -20°C. It is best to avoid repeated freeze/thaw cycles.

      Helpful?

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