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D5314

Sigma-Aldrich

DPQ

≥98% (HPLC), solid

Sinónimos:

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone

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About This Item

Fórmula empírica (notación de Hill):
C18H26N2O2
Número de CAS:
129075-73-6
Peso molecular:
302.41
MDL number:
MFCD01866274
UNSPSC Code:
12352200
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (HPLC)

form

solid

mp

107-109  °C

solubility

DMSO: 1 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2

InChI

1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)

InChI key

RVOUDNBEIXGHJY-UHFFFAOYSA-N

Application

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Biochem/physiol Actions

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.
DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
SLCP4371
SLCL4596
SLCG8652
SLCD4068
SLCB3903

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Sigma-Aldrich

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Anti-cancer drug design, 6(2), 107-117 (1991-05-01)
A series of dihydroisoquinolinones, formally rigid analogs of 3-substituted benzamides, and a series of 2,3-disubstituted benzamides were synthesized and evaluated as inhibitors of poly(ADP-ribose) polymerase. The results indicated that the orientation of the amide with respect to the substituent on
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