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Key Documents

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C5735

SAFC

L-Cystine

Fabricación farmacéutica

Sinónimos:

(R,R)-3,3′-Dithiobis(2-aminopropionicacid)

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About This Item

Fórmula lineal:
[-SCH2CH(NH2)CO2H]2
Número de CAS:
56-89-3
Peso molecular:
240.30
Beilstein/REAXYS Number:
1728094
EC Number:
200-296-3
MDL number:
MFCD00064228
UNSPSC Code:
12352209
NACRES:
NA.26

biological source

non-animal source

Quality Level

400

assay

≥98.5%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

mp

>240 °C (dec.) (lit.)

solubility

1 M HCl: 100 mg/mL

suitability

suitable for manufacturing use

application(s)

pharmaceutical (small molecule)

SMILES string

N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O

InChI

1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

InChI key

LEVWYRKDKASIDU-IMJSIDKUSA-N

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General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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L-Cystine ≥99.7% (TLC)

Sigma-Aldrich

30200

L-Cystine

L-Tirosina

SAFC

T4321

L-Tirosina

L-Cistina dihydrochloride from non-animal source, BioReagent, suitable for cell culture, ≥98.0% dry basis

Sigma-Aldrich

C6727

L-Cistina dihydrochloride

L-Cystine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1323

L-Cystine

Glicina granulated, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

SAFC

1.03669

Glicina

L-Cystine certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

49603

L-Cystine

Antiespumante EX-CELL® gamma irradiated

SAFC

59920C

Antiespumante EX-CELL®

Anne C Conibear et al.
The Journal of biological chemistry, 288(15), 10830-10840 (2013-02-23)
θ-Defensins are ribosomally synthesized cyclic peptides found in the leukocytes of some primate species and have promising applications as antimicrobial agents and scaffolds for peptide drugs. The cyclic cystine ladder motif, comprising a cyclic peptide backbone and three parallel disulfide
Serge-George Rosolen et al.
Advances in experimental medicine and biology, 775, 145-154 (2013-02-09)
In the 70s, the amino acid taurine was found essential for photoreceptor survival. Recently, we found that taurine depletion can also trigger retinal ganglion cell degeneration both in vitro and in vivo. Therefore, evaluation of taurine levels could be a
Philip J Hogg
Nature reviews. Cancer, 13(6), 425-431 (2013-05-11)
Protein action in nature is generally controlled by the amount of protein produced and by chemical modification of the protein, and both are often perturbed in cancer. The amino acid side chains and the peptide and disulphide bonds that bind
Jan Lewerenz et al.
Antioxidants & redox signaling, 18(5), 522-555 (2012-06-07)
The antiporter system x(c)(-) imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is composed of a light chain, xCT, and a heavy chain, 4F2 heavy chain (4F2hc), and, thus
Martijn J Wilmer et al.
American journal of physiology. Renal physiology, 299(5), F905-F916 (2010-09-10)
Renal proximal tubules are highly sensitive to ischemic and toxic insults and are affected in diverse genetic disorders, of which nephropathic cystinosis is the most common. The disease is caused by mutations in the CTNS gene, encoding the lysosomal cystine
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