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C4911

Sigma-Aldrich

Chlorothiazide

thiazide diuretic

Sinónimos:

6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

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About This Item

Fórmula empírica (notación de Hill):
C7H6ClN3O4S2
Número de CAS:
58-94-6
Peso molecular:
295.72
EC Number:
200-404-9
MDL number:
MFCD00058576
UNSPSC Code:
12352202
PubChem Substance ID:
24278150
NACRES:
NA.77
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biological source

synthetic (organic)

Quality Level

100

assay

≥98% (HPLC)

form

powder

mp

>300 °C

solubility

DMF: 50 mg/mL, clear, colorless to very faintly yellow

storage temp.

2-8°C

SMILES string

O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O

InChI

1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

InChI key

JBMKAUGHUNFTOL-UHFFFAOYSA-N

Gene Information

human ... CA1(759) , CA4(762) , SLC12A3(6559)

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General description

Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.[1]

Application

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA).[2] It has also been used to test its effect on blocking pendrin activity.[3]
One of the first in the thiazide class of diuretics.

Biochem/physiol Actions

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration.[4] CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.[4]

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCR4275
MKCP8673
MKCM9229
MKCJ0803
MKBZ6760V

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Emanuele Bernardinelli et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 38(5), 1984-1998 (2016-05-11)
Pendrin is a Cl-/I-/HCO3- exchanger playing a fundamental role in controlling blood pressure and airway function, therefore representing an attractive target for the treatment of hypertensive states and respiratory distresses. A review of the literature regarding the ability of some
Stela Dineva et al.
Journal of human hypertension, 33(11), 766-774 (2019-10-09)
Hypertension is a complex syndrome of multiple hemodynamic, neuroendocrine, and metabolic abnormalities. The goals of treatment in hypertension are to optimally control high blood pressure and to reduce associated cardiovascular morbidity and mortality using the most suitable therapy available. Hydrochlorothiazide
Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: application to dibenz [b, f] azepine-5-carboxamide derivatives
Fortuna A, et al.
Journal of Pharmaceutical Sciences, 101(2), 530-540 (2012)
Julio D Duarte et al.
Expert review of cardiovascular therapy, 8(6), 793-802 (2010-06-10)
Thiazide and thiazide-like diuretics are among the most commonly used antihypertensives and have been available for over 50 years. However, the mechanism by which these drugs chronically lower blood pressure is poorly understood. Possible mechanisms include direct endothelial- or vascular
Saleem Shaikh et al.
Journal of pharmaceutical and biomedical analysis, 48(3), 1055-1057 (2008-09-26)
A simple and precise high performance liquid chromatographic method has been developed and validated for the simultaneous determination of bisoprolol fumarate (BF), and hydrochlorothiazide (HCTZ) in a tablet formulation. Chromatography was carried out at 25 degrees C on a 4.6
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