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C4375

Sigma-Aldrich

N-Carbamyl-L-glutamic acid

≥98.0% (TLC)

Sinónimos:

N-(aminocarbonyl)-L-glutamic acid

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About This Item

Fórmula empírica (notación de Hill):
C6H10N2O5
Número de CAS:
1188-38-1
Peso molecular:
190.15
MDL number:
MFCD00047874
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24892688
NACRES:
NA.26

product name

N-Carbamyl-L-glutamic acid,

assay

≥98.0% (TLC)

Quality Level

200

form

powder

color

white

application(s)

cell analysis

storage temp.

2-8°C

SMILES string

NC(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1

InChI key

LCQLHJZYVOQKHU-VKHMYHEASA-N

Gene Information

human ... CPS1(1373)

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Categorías relacionadas

Biochem/physiol Actions

N-Carbamyl-L-glutamic acid (carglumic acid) is use to study its potential as a replacement therapy for N-acetylglutamate synthetase (NAGS) deficiency and to treat hyperammonemia.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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X Wu et al.
Animal reproduction science, 132(3-4), 187-192 (2012-06-12)
The objectives of this study were to investigate the potential mechanisms of dietary arginine (Arg) and N-carbamoylglutamate (NCG) supplementation on reproductive performance of sows. Twenty-seven crossbred (Landrace×Large White) sows with similar body weight and parity at day (90±1) of gestation
X Wu et al.
Journal of animal science, 90 Suppl 4, 337-339 (2013-02-13)
To evaluate the effects of glutamate (Glu) or combination of Glu and N-carbamylglutamate (NCG) on intestinal mucosa morphology and epithelium cell proliferation, 18 piglets weaned at 21 d (BW 5.56 ± 0.51 kg) were grouped into 3 treatments and fed
X D Liu et al.
Amino acids, 42(6), 2111-2119 (2011-06-04)
Placental vascular formation and blood flow are crucial for fetal survival, growth and development, and arginine regulates vascular development and function. This study determined the effects of dietary arginine or N-carbamylglutamate (NCG) supplementation during late gestation of sows on the
Boris Gebhardt et al.
Molecular genetics and metabolism, 79(4), 303-304 (2003-09-02)
In patients with methylmalonic aciduria (MMA), the accumulating metabolite propiony-CoA results in an inhibition of the urea circle via the decreased synthesis of N-acetylglutamate, an essential activator of carbamylphosphat synthetase (CPS). This results in one of the major clinical problems
B Gebhardt et al.
Journal of inherited metabolic disease, 28(2), 241-244 (2005-05-07)
In patients with propionic aciduria, the accumulating metabolite propionyl-CoA causes a disturbance of the urea cycle via the inhibition of N-acetylglutamate synthesis. Lack of this allosteric activator results in an inhibition of carbamoylphosphate synthase (CPS). This finally leads to hyperammonaemia.
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