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C3821

Sigma-Aldrich

Citrate-dextrose solution (ACD)

sterile-filtered

Sinónimos:

Acid citrate-dextrose, Anticoagulant citrate-dextrose

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About This Item

Número de CAS:
8013-89-6
Número MDL:
MFCD00212913
Código UNSPSC:
12161700
NACRES:
NA.25
En este momento no podemos mostrarle ni los precios ni la disponibilidad

esterilidad

sterile-filtered

Nivel de calidad

200

Formulario

liquid

pH

4.5-5.5

temp. de almacenamiento

2-8°C

Categorías relacionadas

Descripción general

Citrate-dextrose solution (ACD) is an anticoagulant and preservative used routinely for blood storage. The ideal red blood cells shelf life is 21 days when stored in ACD solution.[1] Red blood cells in ACD solution utilize glucose and their viability is impairs when reinfused.[2]

Aplicación

Citrate-dextrose solution (ACD) has been used for dilution of blood for haematological studies.[3] It has also been used as an anticoagulant during blood collection by cardiac puncture from mice[4] and human bone marrow isolation.[5]
For research use only. Not for use in diagnostic procedures.

Acciones bioquímicas o fisiológicas

Useful for anticoagulation of whole blood; erythrocyte survival

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Referencia del producto
Descripción
Precios

08168

Timestrip Plus™ 8 °C

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000343006
0000343006
0000380975
0000334289
0000361083

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Mingming Yang et al.
Experimental and therapeutic medicine, 20(2), 1253-1260 (2020-08-09)
The p53 gene is well known as a key tumor suppressor gene; it is vital for hematopoietic stem cell differentiation and growth. In the present study, the change of platelets (PLTs) in p53 knockout mice (p53-/- mice) was investigated. The
Isolation, expansion and characterisation of mesenchymal stem cells from human bone marrow, adipose tissue, umbilical cord blood and matrix: a comparative study
Secunda R, et al.
Cytotechnology, 67(5), 793-807 (2015)
Comparison of equine platelet function and survival in whole blood collected in acid-citrate-dextrose solution or citrate-phosphate-dextrose-adenine solution
Bozorgmanesh R, et al.
Veterinary Clinical Pathology / American Society For Veterinary Clinical Pathology, 46(2), 262-268 (2017)
Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo
Katz SG, et al.
Molecular and Cellular Biology, 22(9), 3121-3128 (2002)
The storage of hard-packed red blood cells in citrate-phosphate-dextrose (CPD) and CPD-adenine (CPDA-1)
Beutler E and West C
Blood, 54(1), 280-284 (1979)
Ver todos los artículos relacionados

Questions

1–10 of 13 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Is the quality of the ACD solution affected if the bottles are left at ambient temperature (20°C in a temperature-controlled facility) for 48 hours, considering that they are typically required to be refrigerated?

    1 answer

    1. The recommended storage temperature for the ACD solution is between 2-8°C. There is no formal data to suggest that the product can be stored outside of this range without affecting its quality. Additionally, the product is capable of being shipped at ambient temperature for a duration of up to 14 days.

      Helpful?

  4. What is the composition of this citrate-dextrose solution? Is it solution A or B as defined by the US Pharmacopeia?

    1 answer

    1. The composition of the citrate-dextrose solution is as follows:
      1. 22.00 g/L Citric Acid, trisodium salt, dihydrate (C3434)
      2. 7.30 g/L Citric Acid, anhydrous (C0759)
      3. 24.50 g/L D-(+) Glucose (G7528)
      Based on this information, it is likely that the solution is ACD A, which is more commonly used than ACD B as defined by the US Pharmacopeia.

      Helpful?

  5. What is the composition of product C3821, Citrate-dextrose solution (ACD)?

    1 answer

    1. This corresponds to an ACD-A type solution. The composition of this product is as follows:
      1. 22.00 g/L C3434, Citric Acid, trisodium salt, dihydrate
      2. 7.30 g/L C0759, Citric Acid, anhydrous
      3.24.50 g/L G7528, D-(+) Glucose.

      Helpful?

  6. Is product C3821, Acid-Citrate-Dextrose, a concentrate? What ratio of product to whole blood is recommended?

    1 answer

    1. C3821 can be considered a stock solution, and the bottle can be used multiple times. The ratio of ACD or Citrate Dextrose solution can vary from one source to another. A ratio of 1:11 is the more concentrated usage recommended, although dilutions as high as 1:16 are sometimes found in the literature. A good compromise might be a 1:12 dilution.
      Given that there is no preservative in the solution, there is a possibility of contaminating the solution through routine use. Therefore, care should be taken to ensure that the solution does not become contaminated through routine use. The recommended storage temperature is 2-8°C.

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  7. Can it used in prp preparation?

    1 answer

    1. This product is not tested for platelet-rich plasma preparation, however, Acid Citrate-Detrose is commonly used in this procedure. There is no reason to suspect that this item would not be appropriate. This product is intended for research use only and is not suitable for IVD or therapeutic use.

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  8. Hi, I want to order ACD-A solution, I found you have ACD (C3821), I wonder if you can provide the content and concentration of your ACD so that I can compare and see what´s difference between your ACD and ACD-A

    1 answer

    1. This product is equivalent to ACD- A solution.
      The composition is as follows:
      22.00 g/L C3434, Citric Acid, trisodium salt, dihydrate
      7.30 g/L C0759, Citric Acid, anhydrous
      24.50 g/L G7528, D-(+) Glucose (Dextrose)

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  9. HI, I have this product Dextrose solution C3821-10X50ML. How long could I let it at room temps. It was shipped and keeping in shiping for 3 days. Thanks, Chenier

    1 answer

    1. This product is shipped in ambient temperature. Once the product arrives to the address on the order, it is to be stored at 2-8°C by the end-user. Products shipped ambient but stored frozen or refrigerated should be stable in ambient temperature for up to two weeks. Please view this link for more information on Storage and Transport Conditions: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/232/426/storage-transport-conditions-ms.pdf.

      Helpful?

  10. At what concentration should Product C3821, Citrate-dextrose solution, be used?

    1 answer

    1. Use 1 part citrate dextrose solution to 9 parts blood.

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1–10 of 13 Questions  

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