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A4626

Sigma-Aldrich

1-Acetyl-2-phenylhydrazine

≥98%

Sinónimos:

N-Acetyl-N′-phenylhydrazine, acetylphenylhydrazine

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About This Item

Fórmula lineal:
CH3CONHNHC6H5
Número de CAS:
114-83-0
Peso molecular:
150.18
EC Number:
204-055-3
MDL number:
MFCD00008672
UNSPSC Code:
12352127
PubChem Substance ID:
24890888
NACRES:
NA.25

Quality Level

100

assay

≥98%

form

(Powder with Chunk(s) or Crystals with Chunk(s))

mp

128-131 °C (lit.)

SMILES string

CC(=O)NNc1ccccc1

InChI

1S/C8H10N2O/c1-7(11)9-10-8-5-3-2-4-6-8/h2-6,10H,1H3,(H,9,11)

InChI key

UICBCXONCUFSOI-UHFFFAOYSA-N

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Application

1-Acetyl-2-phenylhydrazine (AcPhHZ) which reacts with oxyhaemoglobin to form free radicals may be used to induce haemolytic anaemia for studies of the hematopoietic system.

Biochem/physiol Actions

1-Acetyl-2-phenylhydrazine (AcPhHZ) is a vascular tumor initiator used in experimental animal model.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

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G Bartosz et al.
Clinica chimica acta; international journal of clinical chemistry, 198(3), 239-243 (1991-05-15)
Erythrocytes of Down syndrome patients, having increased activity of superoxide dismutase and glutathione peroxidase, showed a similar increase in intracellular proteolysis upon stimulation with 1 mmol/l phenylhydrazine than normal erythrocytes. There were no differences in the magnitude of Heinz body
High activity antioxidant enzymes protect flying-fox haemoglobin against damage: an evolutionary adaptation for flight?
Reinke NB, O'Brien GM.
Journal of Comparative Pathology, 176, 729-737 (2006)
Y Manabe et al.
The Journal of toxicological sciences, 25(3), 161-165 (2000-09-15)
In this study, a new simple method to measure erythrocyte fragility with stirring of diluted blood (stirring method) was introduced and evaluated with anemic rats given beta-acetylphenylhydrazine (APHZ) or clofibrate. APHZ at a dose of 40 mg/kg caused significant decreases
T Umenai et al.
The Tohoku journal of experimental medicine, 186(3), 181-191 (1999-05-29)
An increase in the number of erythroblasts can be seen to some extent in the bone marrow of rats in the early stage of experimentally induced hemolytic anemia prior to any elevation in the plasma erythropoietin (Epo) level. This observation
Li Jia et al.
Nutrition (Burbank, Los Angeles County, Calif.), 27(11-12), 1194-1201 (2011-05-31)
Whether a specific nutritional support promotes healing of aplastic anemia (AA) patients is still unclear. Therefore, we explored the potential of a high-nucleotide, arginine, and micronutrient nutritional supplement on the nutritional rehabilitation of AA mice. The BALB/c AA mice model
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