A1737

A922500

• Fórmula empírica (notación de Hill): C₂₆H₂₄N₂O₄
• Número de CAS: 959122-11-3
• Peso molecular: 428.48
• MDL number: MFCD12828780
• UNSPSC Code: 12352204
• NACRES: NA.77

Propiedades

• biological source: synthetic (organic)
• Quality Level: 100
• assay: >95% (HPLC)
• form: powder
• mol wt: M_w 428.5
• solubility: DMSO: 10 mg/mL, clear, colorless to greenish-yellow
• storage temp.: −20°C
• SMILES string: N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1
• InChI: 1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
• InChI key: BOZRFEQDOFSZBV-DHIUTWEWSA-N

Descripción

Application

A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.

Biochem/physiol Actions

Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC₅₀ 7 to 24 nM

The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.

Physical form

A922500 is supplied as a crystalline solid.

Preparation Note

A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable