A0233

AS605240

≥98% (HPLC)

• Sinónimos: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
• Fórmula empírica (notación de Hill): C₁₂H₇N₃O₂S
• Número de CAS: 648450-29-7
• Peso molecular: 257.27
• Número MDL: MFCD11100415
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329770591
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: , faint red to orange to dark brown
• solubilidad: DMSO: 1 mg/mL, clear (warmed)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C1NC(=O)C(\S1)=C\c2ccc3nccnc3c2
• InChI: 1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-
• Clave InChI: SQWZFLMPDUSYGV-POHAHGRESA-N

Descripción

Aplicación

AS605240 has been used:

• as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
• as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
• as a class 1A PI3K inhibitor to treat CD4⁺ T cells.

Acciones bioquímicas o fisiológicas

AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.

AS605240 is a potent and selective PI3Kγ inhibitor.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves