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Merck
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325M-1

Sigma-Aldrich

CA-125 (OC125) Mouse Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

diluted ascites fluid

tipo de anticuerpo

primary antibodies

clon

OC125, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (325M-14)
vial of 0.5 mL concentrate (325M-15)
bottle of 1.0 mL predilute (325M-17)
vial of 1.0 mL concentrate (325M-16)
bottle of 7.0 mL predilute (325M-18)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG1κ

control

ovarian carcinoma

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic, membranous

Información sobre el gen

human ... MUC16(94025)

Categorías relacionadas

Descripción general

CA-125 (cancer antigen 125) is a large transmembrane glycoprotein belonging to the mucin family, encoded by the gene MUC16. By immunohistochemistry, CA-125 expression is not identified in normal ovarian tissue, but it is found in the normal cervix, fallopian tube, and endometrium. Positive immunostaining for CA-125 is seen in most ovarian carcinomas and epithelioid mesotheliomas.
Anti-CA-125 antibody reacts with epithelioid malignancies of the ovary, papillary serous carcinoma of the cervix, adenocarcinoma of the endometrium, clear cell adenocarcinoma of the bladder, and epithelioid mesothelioma. The antigen is formalin resistant, permitting the detection of ovarian cancer by immunohistochemistry, although serum assays for this protein are widely used to monitor ovarian cancer. Anti-CA-125 also reacts with antigens in seminal vesicle carcinoma.

Calidad


IVD
IVD
IVD
RUO

Ligadura / enlace

CA-125 Positive Control Slides, Product No. 325S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000418441
0000418441
0000413990
0000413990
0000394824

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J G Quirk et al.
American journal of obstetrics and gynecology, 159(3), 644-649 (1988-09-01)
CA 125 was assayed in amniotic fluid and tissue extracts by immunoradiometric assay, and immunohistochemical studies were performed on paraffin-embedded sections of endometrium, decidua, and fetal membranes with the monoclonal antibody OC 125 used as primary antibody. The concentration of
I Fukazawa et al.
Archives of gynecology and obstetrics, 243(1), 41-50 (1988-01-01)
We studied immunohistochemical stains for TPA and CA125 in patients with benign and malignant gynecologic diseases. The results were as follows: (1) CA125 was not found in ovarian mucinous cystadenocarcinoma but was demonstrated immunohistochemically in 82% of ovarian serous cystadenocarcinomas
C Zhou et al.
The American journal of surgical pathology, 22(1), 113-120 (1998-01-09)
The clinical and pathologic features of 17 cases of papillary serous adenocarcinoma of the cervix (PSCC) were studied in women who ranged in age from 26 to 70 years. There was a bimodal age distribution, with one peak occurring before
I Mylonas et al.
Anticancer research, 23(2A), 1075-1080 (2003-06-25)
The aim of this study was to determine the tissue distribution of CA-125 in normal, hyperplastic and malignant endometrium. Endometrial tissue was obtained from women in proliferative (n = 5), early secretory (ES; n = 4) and late secretory (LS;
E J Nouwen et al.
Cancer research, 46(2), 866-876 (1986-02-01)
Human placental alkaline phosphatase (HPLAP), carcinoembryonic antigen (CEA), and cancer antigen 125 (CA 125) were localized immunohistochemically in paraffin sections of normal lung tissue from 16 patients, using monoclonal antibodies and an indirect avidin-biotin-peroxidase staining procedure. HPLAP and CEA were
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