T4625

Tiamina hydrochloride

reagent grade, ≥99% (HPLC)

• Sinónimos: Aneurina hydrochloride, Vitamina B₁ hydrochloride
• Fórmula empírica (notación de Hill): C₁₂H₁₇ClN₄OS · HCl
• Número de CAS: 67-03-8
• Peso molecular: 337.27
• Beilstein/REAXYS Number: 3851771
• EC Number: 200-641-8
• MDL number: MFCD00012780
• UNSPSC Code: 12352209
• eCl@ss: 34058006
• PubChem Substance ID: 24900057
• NACRES: NA.26

Propiedades

• biological source: synthetic (organic)
• Quality Level: 200
• grade: reagent grade
• assay: ≥99% (HPLC)
• form: powder
• technique(s): HPLC: suitable
• color: white
• mp: 250 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL, clear, colorless
• SMILES string: CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]
• InChI: 1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
• InChI key: DPJRMOMPQZCRJU-UHFFFAOYSA-M

Descripción

General description

Thiamine is a water-soluble vitamin-B complex. Structurally, it possesses a five-membered thiazolium ring and a six-membered amino-pyrimidine ring connected by a methyl group. Thiamine is naturally available in fruits, vegetables, poultry, eggs.

Application

Thiamine hydrochloride has been used as a vitamin supplement to the holidic medium and in bacterial growth medium.

Biochem/physiol Actions

Thiamine is an essential coenzyme in carbohydrate metabolism. Deficiency of thiamine causes beriberi, a neurological and cardiovascular disease. Thiamine is administered in case of deficiency, either due to reduced intake or synthesis. Congenital defect in the thiamine transporter gene SLC19A2 causes thiamine-responsive megaloblastic anemia syndrome (TRMA). Thiamine mimics acetylcholine in brain and possible exerts a role in Alzheimer′s disease. Thiamine deficiency in ruminants causes polioencephalomalacia.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)