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08012

Supelco

1-Deoxynojirimycin

analytical standard

Sinónimos:

1,5-Dideoxy-1,5-imino-D-sorbitol

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About This Item

Fórmula empírica (notación de Hill):
C6H13NO4
Número de CAS:
19130-96-2
Peso molecular:
163.17
Beilstein/REAXYS Number:
3588039
MDL number:
MFCD00063474
UNSPSC Code:
85151701
PubChem Substance ID:
329748539
NACRES:
NA.24

grade

analytical standard

Quality Level

100

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

format

neat

SMILES string

OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI key

LXBIFEVIBLOUGU-JGWLITMVSA-N

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General description

1-Deoxynojirimycin is a polyhydroxypiperidine alkaloid and glucose analog, that has an -NH group substituting the O atom in the pyranose ring. It shows a significant α-glucosidase inhibitory effect in addition to antioxidant, antimicrobial, antidiabetic, antitumor, and anti-inflammatory behavior. It is commonly found in the roots of mulberry trees.

Application

DNJ may be used as a reference standard for the determination of DNJ in:
  • Mulberry leaves by high-performance liquid chromatography (HPLC) equipped with evaporative light scattering detector (ELSD) as well as direct analysis in real-time (DART) ionization source coupled with triple quadrupole tandem mass spectrometry (MS/MS).
  • Silkworms by hydrophilic interaction chromatography (HILIC) with MS/MS operating on multiple reaction monitoring (MRM) mode.
  • Mulberry leaves of 132 varieties belonging to nine Morus species following its derivatization with fluorenylmethyl chloroformate (FMOC-Cl) by high-performance liquid chromatography (HPLC) combined with photodiode array (PDA) detector
  • Development of an analytical method based on hydrophilic interaction chromatography (HILIC) coupled with tandem mass spectrometry (MS/MS) in positive ion electrospray ionization mode in the leaves of 32 cultivars of different Morus species
  • HPLC method-based separation and quantification in the ethanol extracts of the leaves of Morus alba L. and Morus nigra with fluorimetric detection following pre-column derivatization with 9-fluorenylmethyl chloroformate
  • 146 varieties of mulberry fruits from nine genera by HPLC in combination with UV-Vis dual-wavelength detection
  • Human plasma by hybrid quadrupole/linear ion trap tandem mass spectrometry (QTRAP MS/MS).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
BCCM6090
BCCL9843
BCCJ9283
BCCF9487
BCCD8547

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Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: application to pharmacokinetic studies
Nakagawa K, et al.
Bioscience, Biotechnology, and Biochemistry, 72(8), 2210-2213 (2008)
You-Gui Li et al.
PloS one, 8(6), e65892-e65892 (2013-06-12)
We had previously shown that deoxynojirimycin-polysaccharide mixture (DPM) not only decreased blood glucose but also reversed the damage to pancreatic β-cells in diabetic mice, and that the anti-hyperglycemic efficacy of this combination was better than that of 1-deoxynojirimycin (DNJ) or
Katsumi Higaki et al.
Future medicinal chemistry, 5(13), 1551-1558 (2013-09-13)
A growing body of evidence suggests that misfolding of a mutant protein followed by its aggregation or premature degradation in the endoplasmic reticulum is one of the main mechanisms that underlie inherited neurodegenerative diseases, including lysosomal storage diseases. Chemical or
Bi-Qing Li et al.
PloS one, 8(6), e65207-e65207 (2013-06-14)
Acquired immune deficiency syndrome (AIDS) is a severe infectious disease that causes a large number of deaths every year. Traditional anti-AIDS drugs directly targeting the HIV-1 encoded enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) usually suffer from
Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography-tandem mass spectrometry
Nakagawa K, et al.
Analytical Biochemistry, 404(2), 217-222 (2010)
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