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ABS2120

Sigma-Aldrich

Anti-methylglutaryl-lysine

from rabbit

Sinónimos:

3-methylglutaryl (MG)-lysine, MG

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

reactividad de especies (predicha por homología)

all

envase

antibody small pack of 25 μg

técnicas

western blot: suitable

isotipo

IgG

modificación del objetivo postraduccional

unmodified

Descripción general

Acetylation of lysine residues is proteins has emerged as an important mechanism in regulation and coordination of normal and pathophysiological cell metabolism. Lysine 3-methylglutaryl is a newer post-translational protein modification that occurs under normal basal conditions. In murine models of HMG-CoA lyase deficiency, higher levels of protein lysine 3-MGylation are observed. This rabbit polyclonal antibody specifically detects chemically modified proteins containing 3-methylglutaryl lysine modifications, but not unmodified proteins. (Ref.: Wagner, GR et al. (2017). Cell Metabolism 25(4); 823-837).

Especificidad

This rabbit polyclonal antibody detects 3-methylglutaryl (MG)-lysine conjugated to BSA.

Inmunógeno

3-methylglutaryl (MG)-lysine conjugated to BSA.

Aplicación

Anti-methylglutaryl-lysine, Cat. No. ABS2120, is a rabbit polyclonal antibody that detects 3-methylglutaryl-lysine conugated proteins and has been tested for use in Western Blotting.
Research Category
Signaling
Western Blotting Analysis: A representative lot detected methylglutaryl-lysine in Western Blotting applications (Wagner, G.R., et. al. (2017). Cell Metab. 25(4):823-837; Anderson, K.A., et. al. (2017). Cell Metab. 25(4):838-855.e15).

Calidad

Evaluated by Western Blotting with methyl glutaryl BSA conjugate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected 3-methylglutaryl (MG)-lysine in methyl glutaryl BSA conjugate.

Descripción de destino

~75 kDa observed (BSA conjugate). Uncharacterized bands may be observed in some lysate(s).

Forma física

Affinity Purified
Format: Purified
Purified rabbit polyclonal antibody in PBS with 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to lot specific datasheet.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Elma Zaganjor et al.
Cell reports, 36(2), 109345-109345 (2021-07-15)
Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature adipocytes capable of storing nutrients as fat. We profiled cellular metabolite consumption to identify early metabolic drivers of adipocyte differentiation. We find that adipocyte differentiation raises the uptake and consumption

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