565755

γ-Secretase Inhibitor II

The γ-Secretase Inhibitor II controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Sinónimos: γ-Secretase Inhibitor II, MW167
• Fórmula empírica (notación de Hill): C₃₃H₅₇F₂N₅O₉
• Peso molecular: 705.83
• UNSPSC Code: 12352200
• NACRES: NA.54

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 10 mM
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase (IC₅₀ = 13 µM for Aβ). Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase with an IC₅₀ of 13 µM for the inhibition of amyloid β-protein (Aβ) production in β-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 13 µM against γ-secretase

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Wolfe, M.S., et al. 1999. Biochemistry38, 4720.
Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 13170.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable