540211

PTP Inhibitor IV

The PTP Inhibitor IV, also referenced under CAS 329317-98-8, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: PTP Inhibitor IV, bis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene, Protein Tyrosine Phosphatase Inhibitor IV
• Fórmula empírica (notación de Hill): C₂₆H₂₆F₆N₂O₄S₂
• Número de CAS: 329317-98-8
• Peso molecular: 608.62
• Número MDL: MFCD06660111
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white to off-white
• solubilidad: DMSO: 10 mg/mL; acetonitrile: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: FC(F)(F)[S](=O)(=O)Nc1ccc(cc1)C(C)(C)c2ccc(cc2)C(C)(C)c3ccc(cc3)N[S](=O)(=O)C(F)(F)F
• InChI: 1S/C26H26F6N2O4S2/c1-23(2,19-9-13-21(14-10-19)33-39(35,36)25(27,28)29)17-5-7-18(8-6-17)24(3,4)20-11-15-22(16-12-20)34-40(37,38)26(30,31)32/h5-16,33-34H,1-4H3
• Clave InChI: JWNAVYMNAQDLHX-UHFFFAOYSA-N

Descripción

Descripción general

An uncharged, 1,4-di-substituted, phenyl-linked, bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, substrate competitive, active-site-directed inhibitor of protein tyrosine phosphatases (PTP). Reported to inhibit SHP-2 (IC₅₀ = 1.8 µM), PTP1B (IC₅₀ = 2.5 µM), PTP-ε (IC₅₀ = 8.4 µM), PTP-Meg-2 (IC₅₀ = 13 µM), PTP-ς (IC₅₀ = 20 µM), PTP-β (IC₅₀ = 6.4 µM), and PTP-µ (IC₅₀ = 6.7 µM).

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
SHP-2

Product competes with ATP.

Reversible: yes

Target IC₅₀: 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 µM for SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-µ, respectively

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Huang, P., et al. 2003. Bioorg. Med. Chem.11, 1835.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable