176870

Angiotensinogen, Human Plasma

Native angiotensinogen from human plasma that is cleaved by renin to generate angiotensin I. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance.

• Sinónimos: Angiotensinogen, Human Plasma, AGT, Hypertensinogen, Serpin A8
• Número de CAS: 11002-13-4
• Número MDL: MFCD00151759
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (SDS-PAGE)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• técnicas: cell based assay: suitable
• solubilidad: water: soluble
• Nº de acceso NCBI: NM_001384479
• Nº de acceso UniProt: P01019
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... AGT(183)

Descripción

Descripción general

Research area: CELL SIGNALING

Native angiotensinogen from human plasma is an α2-globulin present in plasma at about 7 mg/100 ml.

Angiotensinogen serves as a precursor for the production of angiotensin.[1] In humans, angiotensinogen is composed of 485 amino acids.[2] It is primarily synthesized and continuously secreted by the liver.[3]

Aplicación

Angiotensinogen has been used for the detection and analysis of the complexes formed between angiotensinogen and proform of eosinophil major basic protein (ProMBP) in both serum and amniotic fluid during pregnancy through ELISA.[4]

Acciones bioquímicas o fisiológicas

Angiotensinogen acts as a precursor molecule in the renin-angiotensin-aldosterone system (RAAS) pathway.[5] It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance. Moreover, overactivation of the RAAS system has been associated with the development of several types of cancer, cardiovascular and renal diseases.[1][3][5] Furthermore, in certain cancers angiotensin II has been shown to promote cancer metastasis.[5]

Advertencia

Toxicity: Standard Handling (A)

Forma física

Lyophilized from 50 mM sodium phosphate, 150 mM NaCl, pH 7.0.

Nota de preparación

Please refer to vial label for lot-specific concentration prior to lyophilization.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Jeunemaitre, X., et al. 1992. Cell71, 169.
Tewksbury, D.A. 1983. Fed. Proc.42, 2724.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3