P56100
Pyrazinecarboxylic acid
99%
Sinónimos:
Pyrazinoic acid
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About This Item
Fórmula empírica (notación de Hill):
C5H4N2O2
Número de CAS:
Peso molecular:
124.10
Beilstein/REAXYS Number:
112305
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
assay
99%
form
powder
mp
222-225 °C (dec.) (lit.)
SMILES string
OC(=O)c1cnccn1
InChI
1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)
InChI key
NIPZZXUFJPQHNH-UHFFFAOYSA-N
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Categorías relacionadas
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Mohamed Abdel-Aziz et al.
European journal of medicinal chemistry, 45(8), 3384-3388 (2010-05-22)
A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide-hydrazone derivatives 3a-l were less active than pyrazinamide. In contrast, the N(4)-ethyl-N(1)-pyrazinoyl-thiosemicarbazide 4 showed the highest activity
Michael Groll et al.
Structure (London, England : 1993), 14(3), 451-456 (2006-03-15)
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Wanliang Shi et al.
Science (New York, N.Y.), 333(6049), 1630-1632 (2011-08-13)
Pyrazinamide (PZA) is a first-line tuberculosis drug that plays a unique role in shortening the duration of tuberculosis chemotherapy. PZA is hydrolyzed intracellularly to pyrazinoic acid (POA) by pyrazinamidase (PZase, encoded by pncA), an enzyme frequently lost in PZA-resistant strains
Anthony D Baughn et al.
Antimicrobial agents and chemotherapy, 54(12), 5323-5328 (2010-09-30)
The pyrazinamide (PZA) analog 5-chloropyrazinamide (5-Cl PZA) is active against mycobacterial species, including PZA-resistant strains of Mycobacterium tuberculosis. In M. smegmatis, overexpression of the type 1 fatty acid synthase (FAS I) confers resistance to 5-Cl PZA, a potent FAS I
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The Journal of pharmacology and experimental therapeutics, 320(1), 211-217 (2006-10-18)
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