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P50900

Sigma-Aldrich

Propargylamine

98%

Sinónimos:

2-Propynylamine, 3-Amino-1-propyne

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About This Item

Fórmula lineal:
HC≡CCH2NH2
Número de CAS:
2450-71-7
Peso molecular:
55.08
Beilstein/REAXYS Number:
773681
EC Number:
219-513-8
MDL number:
MFCD00008198
UNSPSC Code:
12352100
PubChem Substance ID:
24898592
NACRES:
NA.22

Quality Level

200

assay

98%

contains

≤2.5% water

refractive index

n20/D 1.449 (lit.)

bp

83 °C (lit.)

density

0.86 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

NCC#C

InChI

1S/C3H5N/c1-2-3-4/h1H,3-4H2

InChI key

JKANAVGODYYCQF-UHFFFAOYSA-N

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Application

Synthesis of a chiral, fluorescent macrocycle by 1,3-dipolar cycloaddition of propargyl amides of carbohydrate-linked amino acids and 9,10-bis(azidomethyl)anthracene.

For use with

Referencia del producto
Descripción
Precios

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

42.8 °F - closed cup

flash_point_c

6 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
SHBR3389
SHBQ4524
SHBR1751
SHBQ0818
SHBQ0817

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Irene Bolea et al.
Journal of neural transmission (Vienna, Austria : 1996), 120(6), 893-902 (2012-12-15)
Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multifaceted pathogenesis. There are at present three Food and Drug Administration-approved drugs based on the "one drug, one target" paradigm (donepezil, galantamine and rivastigmine) that improve symptoms by inhibiting acetylcholinesterase.
Synthesis, 3141-3141 (2006)
Simona Pilotto et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(9), 2752-2757 (2015-03-03)
With its noncatalytic domains, DNA-binding regions, and a catalytic core targeting the histone tails, LSD1-CoREST (lysine-specific demethylase 1; REST corepressor) is an ideal model system to study the interplay between DNA binding and histone modification in nucleosome recognition. To this
David Aguilar et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 16(30), 9287-9296 (2010-06-29)
Propargylamines can be obtained from secondary amines and terminal alkynes in chlorinated solvents by a three- and two-component synthesis catalyzed by gold compounds and nanoparticles (Au-NP) under mild conditions. The use of dichloromethane allows for the activation of two C-Cl
Orit Bar-Am et al.
Journal of Alzheimer's disease : JAD, 21(2), 361-371 (2010-06-18)
The anti-Parkinsonian, irreversible, selective monoamine oxidase (MAO)-B inhibitors, selegiline (deprenyl, (R)-N-methyl-N-(1-phenylpropan-2-yl) prop-2-yn-1-amine) and rasagiline (Azilect, N-propargyl-1(R)-aminoindan), have been proven to possess neuroprotective/neurorestorative activities in cell cultures and animal models of neurodegenerative diseases. Structure-activity studies provide evidence that neuroprotection is associated
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