Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

Ver Toda la documentación

913235

Sigma-Aldrich

Acetylated branched polyethylenimine solution

20% acetylation, suitable for biomedical research

Sinónimos:

Acetylated PEI, Acetylated-PEI25K, Capped PEI

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula lineal:
(C29H63N11O3)mC3H8N2O
UNSPSC Code:
12162002
NACRES:
NA.23

Nombre del producto

Acetylated branched polyethylenimine solution 20% solution, 20% acetylation, suitable for biomedical research

Quality Level

100

form

liquid

concentration

20 wt. % in water

color

pale yellow to yellow

storage temp.

2-8°C

Application

High molecular weight branched PEI is commonly used in gene delivery due to its high transfection efficiency in a broad range of cells. Branched PEI has been used to successfully deliver genetic material both in vitro and in vivo. N-Acetylation of PEI could lower its toxicity. At low degree of substitution (below 25%) resulted in moderate improvement of transfection activity.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
MKCM3641

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

M Laird Forrest et al.
Pharmaceutical research, 21(2), 365-371 (2004-03-23)
Polyethylenimine (PEI) is a highly effective gene delivery vector, but because it is an off-the shelf material, its properties may not be optimal. To investigate the effects of the protonation properties of the polymer, we generated PEI derivatives by acetylating
Nathan P Gabrielson et al.
Biomacromolecules, 7(8), 2427-2435 (2006-08-15)
We previously reported that gene delivery efficiency of 25-kDa, branched polyethylenimine (PEI) increased upon acetylation of up to 43% of the primary amines with acetic anhydride. In the present work, we investigated the effects of further increasing the degree of
Arkadi Zintchenko et al.
Bioconjugate chemistry, 19(7), 1448-1455 (2008-06-17)
Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current study, we generated a number of nontoxic derivates of branched PEI through modification of

Artículos

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico