902667

Propargyl-PEG6-acid

• Sinónimos: 4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
• Fórmula empírica (notación de Hill): C₁₆H₂₈O₈
• Número de CAS: 1951438-84-8
• Peso molecular: 348.39
• MDL number: MFCD28950778
• UNSPSC Code: 12352106
• NACRES: NA.22

Propiedades

• assay: ≥95%
• form: liquid
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent
• refractive index: n/D 1.469
• functional group: alkyne; carboxylic acid
• storage temp.: −20°C
• SMILES string: OC(CCOCCOCCOCCOCCOCCOCC#C)=O

Descripción

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable