374008

2,2,2-Trifluoroethanethiol

95%

• Fórmula lineal: CF₃CH₂SH
• Número de CAS: 1544-53-2
• Peso molecular: 116.11
• MDL number: MFCD00134386
• UNSPSC Code: 12352100
• PubChem Substance ID: 24863272
• NACRES: NA.22

Propiedades

• vapor pressure: 7.85 psi ( 20 °C)
• assay: 95%
• form: liquid
• refractive index: n20/D 1.352 (lit.)
• bp: 34-35 °C (lit.)
• density: 1.305 g/mL at 25 °C (lit.)
• functional group: fluoro; thiol
• SMILES string: FC(F)(F)CS
• InChI: 1S/C2H3F3S/c3-2(4,5)1-6/h6H,1H2
• InChI key: RYRLLAOLJVDVNN-UHFFFAOYSA-N

Descripción

General description

2,2,2-Trifluoroethanethiol is a fluorinated thiol. The microwave spectrum of 2,2,2-trifluoroethanethiol, and its deuterated species, CF₃CH₂SD has been studied. The gas phase acidity and basicity of 2,2,2-trifluoroethanethiol (TFET) has been investigated by Fourier transform ion cyclotron resonance spectroscopy. Reaction of 2,2,2-trifluoroethanethiol on Mo(110) surface was studied using temperature-programmed section, Auger electron and infrared spectroscopies.

2,2,2-Trifluoroethanethiol is basic in nature and forms charge transfer complexes with molecular iodine.

Application

• Advancements in Peptide Synthesis: A novel synthesis of β-thiol phenylalanine showcases the use of 2,2,2-Trifluoroethanethiol in facilitating one-pot ligation-desulfurization chemistry. This technique is pivotal for developing new peptide-based pharmaceuticals, enhancing both the efficiency and versatility of peptide synthesis (Malins et al., 2015).

Información de seguridad

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H224,H302 + H312 + H332,H315,H319,H335
• pcodes: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P403 + P233
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: -11.2 °F - closed cup
• flash_point_c: -24 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves