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202673

Sigma-Aldrich

Arsenic(III) oxide

99.995% trace metals basis

Sinónimos:

ATO, Diarsenic trioxide;, Arsenic trioxide, Arsenous acid

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About This Item

Fórmula empírica (notación de Hill):
As2O3
Número de CAS:
1327-53-3
Peso molecular:
197.84
EC Number:
215-481-4
MDL number:
MFCD00003433
UNSPSC Code:
12161600
eCl@ss:
38080102
PubChem Substance ID:
24852110
NACRES:
NA.22

Quality Level

200

assay

99.995% trace metals basis

form

powder

reaction suitability

core: arsenic
reagent type: catalyst

SMILES string

O=[As]O[As]=O

InChI

1S/As2O3/c3-1-5-2-4

InChI key

IKWTVSLWAPBBKU-UHFFFAOYSA-N

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Categorías relacionadas

General description

Arsenic(III) oxide (ATO) is an inorganic form of arsenic that is used as a therapeutic compound for treating patients with acute promyelocytic leukemia (APL). Many drug-delivery methods are currently being developed using nanotechnology to overcome its poor bioavailability due to rapid clearance from blood.

Application


  • Electrochemical detection applications: A study on La-based perovskites incorporated with functionalized carbon nanofibers highlights the use of arsenic trioxide for the electrochemical detection of roxarsone in water and food samples, providing a method to improve safety and environmental monitoring (John Felix MA et al., 2024).

  • Antiproliferative effects in cancer research: Research demonstrates the inhibitory effects of arsenic trioxide, combined with metformin, on KG1a cell proliferation, suggesting its potential utility in developing antineoplastic strategies (Huang-Li WH et al., 2024).

  • Environmental remediation: A review on manganese oxide-based materials for arsenic removal discusses the application of arsenic trioxide in environmental remediation, focusing on the effectiveness and advancements in arsenic decontamination technologies (Younas M et al., 2024).

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1

target_organs

Respiratory system,Cardio-vascular system,Gastrointestinal tract

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
MKCS6209
MKCQ5308
MKCQ0318
MKCP5657
MKCP1079

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Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers.
Akhtar A, et al.
Journal of biomedical research, 31(3), 177-177 (2017)
Silica nanovehicles endow arsenic trioxide with an ability to effectively treat cancer cells and solid tumors.
Zhao Z, et al.
Journal of Materials Chemistry, 2(37), 6313-6323 (2014)
A facile route to core?shell nanoparticulate formation of arsenic trioxide for effective solid tumor treatment.
Zhang Z, et al.
Nanoscale, 8(7), 4373-4380 (2016)
Ruoshi Xu et al.
Bone research, 6, 33-33 (2018-11-28)
How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal
Cui Li et al.
Toxicology letters, 219(3), 223-230 (2013-04-02)
Arsenic trioxide (As2O3; ATO) is clinically effective in treating acute promyelocytic leukemia (APL); however, it frequently causes cardiotoxic effects. This study was designed to investigate whether ATO could induce apoptosis of cardiac fibroblasts (CFs) that play very important roles in
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