175226
2-Acetylphenothiazine
95%
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About This Item
Fórmula empírica (notación de Hill):
C14H11NOS
Número de CAS:
Peso molecular:
241.31
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Productos recomendados
Quality Level
assay
95%
form
powder
mp
180-185 °C (lit.)
functional group
ketone
thioether
SMILES string
CC(=O)c1ccc2Sc3ccccc3Nc2c1
InChI
1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3
InChI key
JWGBOHJGWOPYCL-UHFFFAOYSA-N
Application
2-Acetylphenothiazine was used as a NADPH oxidase (NOX) inhibitor in human platelet functional responses and intracellular signaling pathways. It was also used in the synthesis of 2-phenothiazin-2′-yl-cinchoninic acid derivatives.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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F Sparatore et al.
Il Farmaco; edizione scientifica, 35(9), 735-751 (1980-09-01)
In order to investigate the effects of the overlapping of cinchophene and phenothiazine structures, connected with antiinflammatory and analgesic activities, several derivatives of 2-phenothiazin-2'-yl-cinchoninic acid were prepared through the condensation of isatin or 5-substituted isatins with 2-acetylphenothiazine or its 10-ter-aminoalkyl
T Schwerd et al.
Mucosal immunology, 11(2), 562-574 (2017-11-02)
Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome sequencing, a novel hemizygous defect in NOX1 encoding NAPDH oxidase 1 was identified in a patient with ulcerative colitis-like VEOIBD. Exome
Nourah A Al Zahrani et al.
Molecules (Basel, Switzerland), 25(19) (2020-10-11)
Based on reported results for the potential medicinal impact of phenothiazine core, as well as the chalcone skeleton that is widely present in many natural products, together with their reported bioactivities, the present work was aimed at combining both moieties
Jessica Weaver et al.
Biochemical and biophysical research communications, 485(2), 290-294 (2017-02-25)
Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell dysfunction. Direct molecular manipulation of NADPH oxidase-1 (NOX-1) has identified
Dong-Jer Shiau et al.
Scientific reports, 10(1), 13582-13582 (2020-08-14)
In many human cancers, including hepatocellular carcinoma (HCC), high density of infiltrating tumor-associated macrophages (TAM) is associated with poor prognosis. Most TAMs express a M2 phenotype subsequently supporting tumor growth. How tumor cells polarize these TAMs to a pro-tumor M2
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