156124
Oxonic acid potassium salt
97%
Sinónimos:
4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt, Allantoxanic acid
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About This Item
Productos recomendados
Quality Level
assay
97%
mp
300 °C (lit.)
SMILES string
[K+].[O-]C(=O)C1=NC(=O)NC(=O)N1
InChI
1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1
InChI key
IAPCTXZQXAVYNG-UHFFFAOYSA-M
Application
Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The possibility of decreasing the gastrointestinal (GI) toxic effects of 5-fluorouracil (5-FU) on the digestive tract such as its injury of cells and induction of diarrhea, without reducing its antitumor activity, was investigated in rats. Oxonic acid was found to
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