SML0060

NB001

≥98% (HPLC)

• Synonym(s): 5-[[2-(6-Amino-9H-purin-9-yl)ethyl]amino]-1-pentanol; HTS 09836
• Empirical Formula (Hill Notation): C₁₂H₂₀N₆O
• CAS Number: 686301-48-4
• Molecular Weight: 264.33
• MDL number: MFCD03086724
• UNSPSC Code: 41106305
• PubChem Substance ID: 329825126
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: H₂O: ≥24 mg/mL
• storage temp.: −20°C
• SMILES string: Nc1ncnc2n(CCNCCCCCO)cnc12
• InChI: 1S/C12H20N6O/c13-11-10-12(16-8-15-11)18(9-17-10)6-5-14-4-2-1-3-7-19/h8-9,14,19H,1-7H2,(H2,13,15,16)
• InChI key: CVPTTZZCRDVGSU-UHFFFAOYSA-N

Description

Application

NB001 may be used in adenylyl cyclase 1-mediated cell signaling studies.

Biochem/physiol Actions

NB001, originally believed to be a selective inhibitor of adenylyl cyclase 1 (AC1), new evidence suggests NB001 does not interact with AC1 directly. NB001 may reduce cAMP accumulation in cells through an unknown mechanism that is dependent on AC1.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable