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MAK106

Sigma-Aldrich

CETP Activity Assay Kit

Supplied by Roar Biomedical, Inc.

Synonym(s):

Cholesteryl ester transfer protein activity assay kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84

usage

sufficient for 100 fluorometric tests

application(s)

pharmaceutical

detection method

fluorometric

relevant disease(s)

cardiovascular diseases

storage temp.

2-8°C

Gene Information

human ... CETP(1071)

General description

Cholesteryl ester transfer protein (CETP) is present in normal human plasma. The protein transfers neutral lipids from high density lipoproteins (HDL) to very low density lipoprotein (VLDL) and low density lipoprotein (LDL). CETP plays an important role in lipoprotein metabolism and influences the reverse cholesterol transport pathway. The method is useful for measuring CETP activity in plasma or serum in all species that express CETP.

Application

Cholesteryl ester transfer protein (CETP) activity Assay Kit has been used for measurement of CETP activity in the plasma samples.

Features and Benefits

Compatible with high-throughput handling systems.

Suitability

Suitable for the detection of cholesteryl ester transfer protein (CETP) in plasma / serum (fresh or frozen), recombinant or purified CETP.

Principle

The CETP Activity Assay Kit uses a proprietary substrate that enables the detection of CETP-mediated transfer of neutral lipid from the substrate to a physiological acceptor. The transfer activity results in an increase in fluorescence intensity (λEx=535 nm/λEm=587 nm). In a total volume of 200 μL, the assay is linear from 0.2 to 0.8 μL of normal human plasma. Assay results not affected by endogenous plasma HDL, LDL or VLDL concentrations.

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Storage Class Code

10 - Combustible liquids


Certificates of Analysis (COA)

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Thor Ueland et al.
The Journal of clinical endocrinology and metabolism, 105(3) (2019-10-31)
Cholesteryl ester transfer protein (CETP) regulates high-density lipoprotein (HDL) cholesterol levels and interaction between glucose, and HDL metabolism is central in the development of diabetes. We hypothesized that CETP levels would be regulated in diabetic pregnancies. We tested the hypothesis
Catherine J McNeal et al.
Cardiovascular research, 98(1), 83-93 (2013-01-29)
We discovered that some adults with coronary heart disease (CHD) have a high density lipoprotein (HDL) subclass which induces human aortic smooth muscle cell (ASMC) apoptosis in vitro. The purpose of this investigation was to determine what properties differentiate apoptotic
Lisa Sawrey-Kubicek et al.
The American journal of clinical nutrition, 110(3), 617-627 (2019-06-07)
Postmenopausal women are at higher risk for cardiovascular disease (CVD) than their younger counterparts. HDL cholesterol is a biomarker for CVD risk, but the function of HDL may be more important than HDL cholesterol in deciphering disease risk. Although diet
Zhaosha Li et al.
Biochemical pharmacology, 84(6), 821-829 (2012-07-04)
The anti-dyslipidemic drug niacin has recently been shown to reduce the hepatic expression and plasma levels of CETP. Since liver macrophages contribute to hepatic CETP expression, we investigated the role of macrophages in the CETP-lowering effect of niacin in mice.
Tatjana Josefs et al.
Circulation research, 128(6), 690-705 (2021-02-04)
[Figure: see text].

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