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K0889

Sigma-Aldrich

Anti-Kinesin 5A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD07370384
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

bovine, human, mouse

technique(s)

western blot: 0.4 μg/mL using mouse neuronal cell lysate and human retinal extracts

UniProt accession no.

Q12840

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KIF5A(3798)
mouse ... Kif5a(16572)

General description

The gene KIF5A (kinesin family member 5A) is mapped to human chromosome 12. The encoded kinesin is expressed in all neurons, and present in neuronal cytoplasm, which includes the cell body, dendrites, and axon.

Immunogen

synthetic peptide corresponding to amino acid residues 1007-1027 from mouse kinesin 5A.

Application

Anti-Kinesin 5A antibody produced in rabbit has been used in immunofluorescence and immunohistochemistry.

Biochem/physiol Actions

The gene KIF5A (kinesin family member 5A) encodes a kinesin heavy chain that may be involved in the microtubule-dependent slow axonal transport of neurofilament proteins.
Mutations in this gene have been associated with hereditary spastic paraplegia.

Physical form

Solution in phosphate buffered saline containing 1 mg/mL BSA and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A.
Xia CH
The Journal of Cell Biology, 161, 55-66 (2003)
Evan Reid et al.
American journal of human genetics, 71(5), 1189-1194 (2002-10-02)
We have identified a missense mutation in the motor domain of the neuronal kinesin heavy chain gene KIF5A, in a family with hereditary spastic paraplegia. The mutation occurs in the family in which the SPG10 locus was originally identified, at
Ping Shi et al.
Biochimica et biophysica acta, 1802(9), 707-716 (2010-06-01)
Transport of material and signals between extensive neuronal processes and the cell body is essential to neuronal physiology and survival. Slowing of axonal transport has been shown to occur before the onset of symptoms in amyotrophic lateral sclerosis (ALS). We
Ingo Spitzbarth et al.
Brain and behavior, 6(7), e00472-e00472 (2016-06-02)
CDV-DL (Canine distemper virus-induced demyelinating leukoencephalitis) represents a spontaneously occurring animal model for demyelinating disorders. Axonopathy represents a key pathomechanism in this disease; however, its underlying pathogenesis has not been addressed in detail so far. This study aimed at the
S Schwarz et al.
Scientific reports, 10(1), 5380-5380 (2020-03-28)
Dogs share many chronic morbidities with humans and thus represent a powerful model for translational research. In comparison to rodents, the canine ganglioside metabolism more closely resembles the human one. Gangliosides are components of the cell plasma membrane playing a

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