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H2042

Sigma-Aldrich

Histone H2A human

Synonym(s):

Histone, Human

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About This Item

CAS Number:
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

recombinant

expressed in E. coli

form

liquid

concentration

1 mg/mL

UniProt accession no.

application(s)

cell analysis

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... H2AC20(8338)

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General description

Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA to form nucleosomes. A nucleosome comprises an octameric core histone made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B. The 147 DNA base pairs are wrapped around the histone complex. H2A consists of a C-terminal tail extending out of the nucleosome core particle.

Application

Histone H2A human has been used as a neutrophil extracellular trap (NET) to study its effects on the membrane integrity and viability of macrophages (MFS) and dendritic cells (DCS). It has also been used in far-western blot analysis for protein identification.

Biochem/physiol Actions

Histones modulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. N and C terminal tails undergo post-translational modifications (PTMs) altering DNA wrapping and chromatin regulation.

Physical form

Supplied in 20 mM Na3PO4, pH 7.0, 0.3 M NaCl and 1 mM EDTA

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Carc. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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