330200-M

Ecotin, E. coli

A potent, broad range inhibitor of serine proteases.

• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥90% (SDS-PAGE)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• storage temp.: −70°C

Description

General description

A potent, broad range inhibitor of serine proteases.

A potent, broad range inhibitor of serine proteases. Exhibits picomolar binding constant for the inhibition of chymotrypsin, elastase, Factor Xa, Factor XIIa, kallikrein, and trypsin. Also acts as an effective inhibitor of collagenase.

A potent, broad range inhibitor or serine proteases. Exhibits picomolar binding constant for the inhibition of chymotrypsin, elastase, Factor Xa, Factor XIIa, kallikrein, and trypsin. Also an effective inhibitor of collagenase and granzyme B.

Biochem/physiol Actions

Primary Target
serine proteases

Product does not compete with ATP.

Target IC₅₀: 1 pM against serine proteases

binds trypsin in the picomolar range

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 1.0 mM HCl.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

McGrath, M.E., et al. 1995. Protein Sci. 4, 141.
Seong, I.S., et al. 1994. J. Biol. Chem. 269, 21915.
McGrath, M.E., et al. 1991. J. Biol. Chem. 266, 6620.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable