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229172

Sigma-Aldrich

1,2-Diethylhydrazine dihydrochloride

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About This Item

Linear Formula:
C2H5NHNHC2H5 · 2HCl
CAS Number:
Molecular Weight:
161.07
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

mp

169 °C (dec.) (lit.)

SMILES string

Cl[H].Cl[H].CCNNCC

InChI

1S/C4H12N2.2ClH/c1-3-5-6-4-2;;/h5-6H,3-4H2,1-2H3;2*1H

InChI key

NMTDWUVFGOBBAX-UHFFFAOYSA-N

Application

1,2-Diethylhydrazine dihydrochloride was used in the synthesis of 4,5-dihydro-pyrazole, pyrazolidine and 1,2-dihydro-phthalazine derivatives.
Reactant involved in:
  • Bromopyridazinedione-mediated protein and peptide bioconjugation
  • Synthesis of human neutrophil proteinase 3 inhibitors
  • Three-component cascade processes for sythesis of aminoisoindolones and phthalazones
  • Stereoselective heterocyclization for synthesis of substituted hexahydropyrazolodiazepinecarboxylates
  • Synthesis of azacycloalkanes, isoindoles, pyrazole, pyrazolidine, and phthalazine derivatives

Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Yuhong Ju et al.
The Journal of organic chemistry, 71(1), 135-141 (2006-01-04)
[reactions: see text] The synthesis of nitrogen-containing heterocycles from alkyl dihalides (ditosylates) and primary amines and hydrazines via a simple and efficient cyclocondensation in an alkaline aqueous medium that occurs under microwave irradiation is described. This improved greener synthetic methodology

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